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HOXB3 Knockout Cell Lines

Gene: HOXB3

Official Full Name: homeobox B3provided by HGNC

Gene Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37249 HOXB3 Knockout cell line (HeLa) Human HOXB3 1:3~1:6 Negative Online Inquiry
KO37250 HOXB3 Knockout cell line (HCT 116) Human HOXB3 1:2~1:4 Negative Online Inquiry
KO37251 HOXB3 Knockout cell line (HEK293) Human HOXB3 1:3~1:6 Negative Online Inquiry
KO37252 HOXB3 Knockout cell line (A549) Human HOXB3 1:3~1:4 Negative Online Inquiry

Background

HOXB3 Gene Knockout Cell Lines are genetically engineered cell lines designed to silence the expression of the HOXB3 gene, a member of the homeobox gene family that plays a critical role in developmental processes and gene regulation. By utilizing CRISPR-Cas9 technology, these cell lines enable researchers to investigate the specific functions of HOXB3 in various biological contexts, including embryonic development, stem cell differentiation, and cancer biology. The loss of HOXB3 expression allows for a deeper understanding of its regulatory mechanisms and interactions with other genes, a vital aspect for studies aiming to elucidate development-related pathways and disease mechanisms.

The key function of these knockout cell lines lies in their ability to serve as an experimental model for functional genomics. By observing changes in cellular behavior and phenotype upon the manipulation of HOXB3 expression, researchers can identify the gene's role in cellular processes such as proliferation, migration, and apoptosis. Furthermore, these cell lines can be pivotal for drug screening and developmental biology studies, where insights into gene interactions can inform therapeutic strategies and regenerative medicine approaches.

The scientific importance of HOXB3 Gene Knockout Cell Lines in research is underscored by their applicability in clinical settings, particularly in understanding the molecular basis of diseases where HOXB3 is implicated. Their use can lead to novel target identification for therapeutic interventions, particularly in cancers associated with aberrant homeobox gene expression.

Compared to conventional cell lines, our HOXB3 Gene Knockout Cell Lines offer a more precise tool for probing gene function without the confounding effects of endogenous expression. This specificity provides researchers with a high-fidelity model, allowing for reproducible results and clearer insights into gene regulation dynamics.

Given the increasing focus on personalized medicine and targeted therapies, the ability to specifically manipulate genes like HOXB3 offers immense value for researchers and clinicians alike. This product stands as a testament to our commitment to advancing biomedical research. Our company's expertise in genetic engineering and commitment to high-quality products ensures that HOXB3 Gene Knockout Cell Lines support groundbreaking discoveries and innovative therapeutic developments.

Please note that all services are for research use only. Not intended for any clinical use.

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