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HOXA3 Knockout Cell Lines

Gene: HOXA3

Official Full Name: homeobox A3provided by HGNC

Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37305 HOXA3 Knockout cell line (HCT 116) Human HOXA3 1:2~1:4 Negative Online Inquiry
KO37306 HOXA3 Knockout cell line (HEK293) Human HOXA3 1:3~1:6 Negative Online Inquiry
KO37307 HOXA3 Knockout cell line (A549) Human HOXA3 1:3~1:4 Negative Online Inquiry

Background

HOXA3 Gene Knockout Cell Lines are specially engineered cellular models designed for studying the functional role of the HOXA3 gene in various biological processes. The HOXA3 gene is a critical member of the homeobox gene family, which encodes transcription factors pivotal in developmental biology and cancer research. By employing CRISPR-Cas9 technology, these cell lines are generated to disrupt the HOXA3 gene, enabling researchers to investigate the implications of its absence in cellular behavior, differentiation, and gene regulation pathways.

The functioning of HOXA3 Gene Knockout Cell Lines allows for the assessment of specific cellular mechanisms influenced by developmental genes. Through the analysis of these knockout models, scientists can delve into the impact of HOXA3 on lineage specification, apoptosis, and oncogenic transformation. These insights are crucial not only for understanding embryonic development but also for elucidating the molecular underpinnings of various cancers where HOXA3 may play a pivotal role.

The scientific importance of these cell lines lies in their applicability to both in vitro and preclinical studies, where they enable high-throughput screening and targeted therapeutic evaluation. Researchers in developmental biology, oncology, and regenerative medicine can leverage these models to formulate hypotheses and validate drug targets linked to HOXA3 functions.

One of the standout advantages of using HOXA3 Gene Knockout Cell Lines is their reliability and specificity compared to traditional methods of gene silencing, such as RNA interference. These cells provide a permanent and stable alteration in gene expression, facilitating reproducible results across experiments. Additionally, the unparalleled precision of CRISPR technology ensures that off-target effects are minimized, offering confidence in experimental outcomes.

As a product of our advanced genetic engineering capabilities, HOXA3 Gene Knockout Cell Lines represent a valuable asset to researchers and clinicians aiming to expand their understanding of gene function and its implications for human health. Our commitment to innovation in biological research tools is evident through our comprehensive expertise in developing high-quality, reliable products that support groundbreaking discoveries in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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