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HOOK1 Knockout Cell Lines

Gene: HOOK1

Official Full Name: hook microtubule tethering protein 1provided by HGNC

Gene Summary: This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22616 HOOK1 Knockout cell line (HeLa) Human HOOK1 1:3~1:6 Negative Online Inquiry
KO22617 HOOK1 Knockout cell line (HCT 116) Human HOOK1 1:2~1:4 Negative Online Inquiry
KO22618 HOOK1 Knockout cell line (HEK293) Human HOOK1 1:3~1:6 Negative Online Inquiry
KO22619 HOOK1 Knockout cell line (A549) Human HOOK1 1:3~1:4 Negative Online Inquiry

Background

HOOK1 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the HOOK1 gene, which encodes a protein implicated in intracellular transport and cellular signaling pathways. By disrupting this gene, these cell lines offer a unique platform for studying the functional roles of HOOK1 in various biological processes, including cell migration, adhesion, and pathogen response.

The primary mechanism by which HOOK1 gene knockout operates involves the use of CRISPR-Cas9 technology, allowing for precise editing of the genomic DNA. Following successful gene disruption, researchers can analyze the downstream effects on signaling cascades, organelle dynamics, and even disease models, thereby elucidating the potential implications of HOOK1 in oncogenesis and other pathological conditions.

Scientifically, these knockout cell lines serve as critical tools in research settings where understanding the underlying molecular mechanisms is paramount. They can be leveraged in drug discovery, target validation, and functional genomics, thus enhancing knowledge in areas such as cancer biology, immunology, and neurobiology. Furthermore, the HOOK1 knockout model can aid in exploring therapeutic interventions aimed at modulating the associated signaling pathways.

Compared to alternative methods like RNA interference or traditional chemical inhibitors, the HOOK1 Gene Knockout Cell Lines offer more stable and reproducible insights due to the permanent loss of the gene expression. This allows for consistent experimentation over time, reducing variability commonly observed with transient knockdowns.

Researchers and clinicians will find immense value in these cell lines, as they provide an efficient and reliable way to delve into genetic functions and their implications in health and disease. The availability of HOOK1 Gene Knockout Cell Lines empowers users to design impactful experiments and translate findings into potential therapeutic options.

Our company is dedicated to advancing life sciences through the provision of high-quality biological products, including these innovative gene knockout models. Our expertise in genetic engineering ensures that each product meets rigorous scientific standards, thus enabling researchers to explore the frontiers of biological research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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