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HNRNPF Knockout Cell Lines

Gene: HNRNPF

Official Full Name: heterogeneous nuclear ribonucleoprotein Fprovided by HGNC

Gene Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37287 HNRNPF Knockout cell line (HeLa) Human HNRNPF 1:3~1:6 Negative Online Inquiry
KO37288 HNRNPF Knockout cell line (HCT 116) Human HNRNPF 1:2~1:4 Negative Online Inquiry
KO37289 HNRNPF Knockout cell line (HEK293) Human HNRNPF 1:3~1:6 Negative Online Inquiry
KO37290 HNRNPF Knockout cell line (A549) Human HNRNPF 1:3~1:4 Negative Online Inquiry

Background

HNRNPF Gene Knockout Cell Lines are advanced cellular models in which the HNRNPF gene has been intentionally disrupted, allowing researchers to study the functions and roles of this significant RNA-binding protein. HNRNPF (Heterogeneous Nuclear Ribonucleoprotein F) is known to participate in various cellular processes, including pre-mRNA splicing, RNA transport, and the regulation of gene expression, making it essential to the understanding of both normal physiological processes and disease states.

The key function of HNRNPF Gene Knockout Cell Lines lies in their ability to provide insights into how the absence of HNRNPF influences cellular behavior and gene regulatory networks. Mechanistically, these knockout models facilitate the analysis of downstream effects on mRNA splicing and stability, thereby revealing potential pathways that might contribute to diseases such as cancer, neurodegeneration, and various genetic disorders. By observing the phenotypic and transcriptomic changes that occur in these cell lines compared to wild-type counterparts, researchers can better understand the critical role of HNRNPF in cellular homeostasis and pathology.

In scientific research and clinical applications, HNRNPF Gene Knockout Cell Lines offer invaluable tools for investigating the complex interactions within the RNA life cycle and their implications in human health. When exploring therapeutic strategies, these models can serve as platforms to screen for potential drugs that target specific RNA-binding proteins or to evaluate the efficacy of gene editing therapies.

Compared to alternative cell lines or models that might not adequately replicate the physiological effects of HNRNPF, our knockout cell lines are precisely engineered for maximal fidelity and reproducibility. This ensures that researchers are equipped with reliable data to draw robust conclusions from their experiments.

Valuable to researchers, clinicians, and biotech companies alike, HNRNPF Gene Knockout Cell Lines enable the exploration of innovative research questions and drive the development of new therapeutic approaches. Our company specializes in providing high-quality biological research tools, backed by extensive experience in genetic engineering and cell line development, ensuring that our products meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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