Gene: HM13
Official Full Name: histocompatibility minor 13provided by HGNC
Gene Summary: The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06213 | HM13 Knockout cell line (HeLa) | Human | HM13 | 1:3~1:6 | Negative | Online Inquiry |
KO06214 | HM13 Knockout cell line (HCT 116) | Human | HM13 | 1:2~1:4 | Negative | Online Inquiry |
KO06215 | HM13 Knockout cell line (HEK293) | Human | HM13 | 1:3~1:6 | Negative | Online Inquiry |
KO06216 | HM13 Knockout cell line (A549) | Human | HM13 | 1:3~1:4 | Negative | Online Inquiry |
HM13 Gene Knockout Cell Lines are sophisticated, genetically modified cell lines specifically designed to facilitate the study of gene function and the underlying molecular mechanisms of various biological processes. Utilizing advanced CRISPR-Cas9 technology, these cell lines have been engineered to disrupt the HM13 gene, providing researchers with a powerful tool to investigate the role of HM13 in cellular pathways, disease progression, and therapeutic response.
The key functionality of the HM13 Gene Knockout Cell Lines lies in their ability to exhibit a phenotypic shift that enhances the understanding of gene-specific effects. By completely ablating HM13 expression, researchers can observe changes in cellular behavior, signaling cascades, and gene expression profiles. This allows for valuable insights into how HM13 influences critical processes such as cell proliferation, apoptosis, and differentiation.
The scientific importance of these cell lines is highlighted by their broad applications in fundamental research, drug discovery, and preclinical studies. They serve as essential models for investigating cancer biology, regenerative medicine, and the development of targeted therapies. By providing a platform for evaluating potential therapeutic interventions, HM13 Gene Knockout Cell Lines contribute substantially to advancing the field of biomedical research.
Unique advantages of the HM13 Gene Knockout Cell Lines include their high specificity, reproducibility, and robust performance in various assays compared to traditional knockdown methods. Unlike RNA interference techniques that can result in incomplete gene silencing, these knockout cell lines ensure the complete abrogation of target gene activity, offering unparalleled accuracy in experimental outcomes.
Key to their value, HM13 Gene Knockout Cell Lines support researchers and clinicians seeking to unravel complex biological questions and develop innovative therapeutic strategies. With these models, users can confidently pursue groundbreaking research with the assurance of precise gene targeting.
At [Your Company Name], our commitment to advancing scientific research through innovative biological products is unwavering. We leverage our expertise in molecular biology and genetic engineering to offer high-quality cell lines that empower the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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