Gene: HINT1
Official Full Name: histidine triad nucleotide binding protein 1provided by HGNC
Gene Summary: This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37372 | HINT1 Knockout cell line (HeLa) | Human | HINT1 | 1:3~1:6 | Negative | Online Inquiry |
KO37373 | HINT1 Knockout cell line (HCT 116) | Human | HINT1 | 1:2~1:4 | Negative | Online Inquiry |
KO37374 | HINT1 Knockout cell line (HEK293) | Human | HINT1 | 1:3~1:6 | Negative | Online Inquiry |
KO37375 | HINT1 Knockout cell line (A549) | Human | HINT1 | 1:3~1:4 | Negative | Online Inquiry |
HINT1 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the HINT1 gene, a nucleoside hydrolase implicated in various cellular processes, including apoptosis, stress response, and metabolism. These knockout cell lines allow researchers to study the functional role of HINT1 in both physiological and pathological contexts, enabling insightful investigations into disease mechanisms, particularly those related to cancer and neurological disorders.
The mechanism underlying HINT1 gene knockout involves targeted genomic editing techniques, such as CRISPR/Cas9 or RNA interference, which effectively silence the gene’s expression. This functional depletion offers a unique opportunity to analyze downstream signaling pathways, cellular behavior, and gene interactions in a controlled environment. Researchers can assess how the loss of HINT1 affects cell proliferation, survival, and responses to pharmacological agents, leading to a deeper understanding of its biological significance.
Scientifically, HINT1 gene knockout cell lines hold immense importance across numerous research disciplines, providing invaluable models for elucidating molecular pathways and developing novel therapeutic strategies. In clinical settings, these cell lines can serve as platforms for drug screening, toxicity assessments, and biomarker discovery, advancing personalized medicine approaches.
Distinct from conventional cell lines, HINT1 knockout models deliver precise gene editing, ensuring reproducibility and reliability in research outcomes. Their highly specific application to HINT1-related studies renders them a crucial resource for targeted genetic investigations, offering a level of specificity that general models cannot match.
For researchers and clinicians seeking to unravel the complexities of cellular behavior or translate findings into potential therapeutic applications, HINT1 Gene Knockout Cell Lines are indispensable tools. Our company specializes in providing high-quality biological products tailored to enhance research capabilities. With expertise in genetic engineering, we are committed to supporting the scientific community in their quest for knowledge and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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