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HERC3 Knockout Cell Lines

Gene: HERC3

Official Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by HGNC

Gene Summary: This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33738 HERC3 Knockout cell line (HeLa) Human HERC3 1:3~1:6 Negative Online Inquiry
KO33739 HERC3 Knockout cell line (HCT 116) Human HERC3 1:2~1:4 Negative Online Inquiry
KO33740 HERC3 Knockout cell line (A549) Human HERC3 1:3~1:4 Negative Online Inquiry

Background

HERC3 Gene Knockout Cell Lines are specialized cellular models engineered to lack the HERC3 gene, known for its role in the regulation of ubiquitin-mediated protein degradation. This biological product serves as a critical tool in both fundamental and applied research, allowing scientists to investigate the effects of the HERC3 gene on various cellular processes, including signaling pathways, cell cycle regulation, and stress responses.

The key function of these knockout cell lines involves elucidating the biological impact of HERC3 ablation, thereby assisting researchers in understanding the gene's contributions to disease mechanisms, particularly in cancer and neurodegeneration. By using CRISPR-Cas9 technology or other gene-editing techniques, these cell lines facilitate accurate modeling of disease states, enabling targeted exploration of therapeutic interventions that may reverse or diminish the pathological effects caused by the absence of HERC3.

The scientific importance of HERC3 Gene Knockout Cell Lines lies in their applications in drug discovery, genetic studies, and pathway analyses. They provide a controlled environment to assess cellular behavior in response to potential therapeutics, thereby accelerating translational research from bench to bedside. Moreover, these knockout lines can be combined with various assays, such as Western blotting and flow cytometry, to quantify protein expressions and elucidate cellular interactions.

One significant advantage of HERC3 Gene Knockout Cell Lines over traditional cell lines is their specificity in targeting an individual gene, which limits off-target effects and improves experimental reliability. Additionally, these customized cell lines are invaluable for researchers seeking to uncover insights into the gene's functional roles and interactions, ultimately contributing to a deeper understanding of complex biological systems.

For researchers, clinicians, and pharmaceutical companies, utilizing HERC3 Gene Knockout Cell Lines translates into enhanced research capabilities and more robust experimental data, increasing the potential for groundbreaking discoveries. Our company specializes in providing high-quality biological products tailored to meet the rigorous demands of research and clinical applications, backed by our commitment to scientific excellence and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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