Gene: HECTD1
Official Full Name: HECT domain E3 ubiquitin protein ligase 1provided by HGNC
Gene Summary: Enables ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to act upstream of or within several processes, including chordate embryonic development; circulatory system development; and protein ubiquitination. Predicted to be active in nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04820 | HECTD1 Knockout cell line (HeLa) | Human | HECTD1 | 1:3~1:6 | Negative | Online Inquiry |
KO04821 | HECTD1 Knockout cell line (HCT 116) | Human | HECTD1 | 1:2~1:4 | Negative | Online Inquiry |
KO04822 | HECTD1 Knockout cell line (HEK293) | Human | HECTD1 | 1:3~1:6 | Negative | Online Inquiry |
KO04823 | HECTD1 Knockout cell line (A549) | Human | HECTD1 | 1:3~1:4 | Negative | Online Inquiry |
HECTD1 Gene Knockout Cell Lines are genetically modified cellular models designed to facilitate the study of the HECTD1 gene, which encodes a member of the HECT-type E3 ubiquitin ligases. This gene plays a crucial role in protein ubiquitination, a post-translational modification process involved in various cellular functions, including protein degradation, cell cycle regulation, and responses to stress signals. By knocking out the HECTD1 gene, these cell lines offer researchers a unique opportunity to elucidate the specific pathways and mechanisms influenced by HECTD1, thereby enhancing our understanding of its role in cellular homeostasis and disease states.
The primary function of HECTD1 Gene Knockout Cell Lines lies in their ability to mimic the loss of HECTD1 in vivo, allowing researchers to observe the resultant phenotypic and functional changes. This model is particularly vital for elucidating the consequences of HECTD1 deficiency, which has been implicated in various conditions, including certain cancers and neurodegenerative diseases. By employing CRISPR/Cas9 technology to achieve precise gene editing, these knockout cell lines enable high-fidelity studies, providing insights into the pathophysiology associated with HECTD1 dysfunction.
In scientific research, the ability to access such targeted cell lines contributes significantly to advancing our understanding of gene function, making them invaluable for both basic research and therapeutic investigations. The specific knockout of the HECTD1 gene allows for the investigation of potential compensatory mechanisms and gene interactions, offering a comprehensive insight into cellular behaviors under altered genetic conditions. Moreover, these cell lines can serve as a robust platform for drug discovery and screening, particularly for compounds that may reactivate or compensate for the loss of HECTD1 function.
What sets our HECTD1 Gene Knockout Cell Lines apart from alternative products is the rigorous quality control and validation processes they undergo. Our cell lines are characterized for consistent performance and reproducibility, essential for high-impact research outcomes. Additionally, we provide extensive technical support and resources to assist researchers in efficiently utilizing these models, optimizing their experimental designs.
For researchers and clinicians focused on understanding ubiquitin signaling and its implications in human disease, our HECTD1 Gene Knockout Cell Lines offer a powerful tool that can significantly enhance the breadth and depth of scientific inquiry. With years of expertise in genetic modification and biotechnology, our company is committed to supporting the scientific community through innovative products that empower research and contribute to therapeutic advances.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.