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H4C9 Knockout Cell Lines

Gene: H4C9

Official Full Name: H4 clustered histone 9provided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34266 H4C9 Knockout cell line (HeLa) Human H4C9 1:3~1:6 Negative Online Inquiry
KO34267 H4C9 Knockout cell line (HEK293) Human H4C9 1:3~1:6 Negative Online Inquiry

Background

H4C9 Gene Knockout Cell Lines are specialized cellular models engineered to lack specific genes, allowing for the investigation of gene functions and pathways in a controlled environment. Utilizing CRISPR-Cas9 technology, these cell lines provide researchers with potent tools to elucidate gene roles in various biological processes, including disease mechanisms and drug response. Each knockout is characterized by its complete inactivation of the target gene, minimizing off-target effects, which enhances the reliability of experimental outcomes.

Key functions of H4C9 Gene Knockout Cell Lines include the capacity to study gene essentiality, signaling pathways, and interactions within cellular networks. By enabling precise genetic modifications, these cell lines facilitate various assays, including proliferation, apoptosis, and metabolic studies, advancing our understanding of cellular behavior under different biological contexts.

Scientifically, these knockout cell lines hold significant importance in both research and clinical settings. They are invaluable for validating therapeutic targets, optimizing drug discovery processes, and enhancing personalized medicine initiatives. Moreover, they are essential for modeling diseases such as cancer, where signaling pathways are often disrupted by mutations in specific genes.

Compared to traditional methods of achieving gene knockouts, such as RNA interference or chemical mutagenesis, H4C9 Gene Knockout Cell Lines offer unparalleled efficiency and accuracy. Their generation is straightforward and reproducible, yielding consistent results across experiments. Furthermore, these lines can be tailored to closely mimic the genetic landscape of specific cancers or other diseases, providing researchers with a robust platform for disease modeling.

The value of H4C9 Gene Knockout Cell Lines is clear—they assist researchers and clinicians in bridging fundamental biology with clinical applications, leading to the development of innovative therapeutic strategies. As experts in biological products, our company is committed to delivering top-tier cellular models backed by rigorous quality control and extensive scientific support, ensuring that our customers have the tools necessary to advance their research goals effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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