Gene: H3C3
Official Full Name: H3 clustered histone 3provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34246 | H3C3 Knockout cell line (A549) | Human | H3C3 | 1:3~1:4 | Negative | Online Inquiry |
H3C3 Gene Knockout Cell Lines are a specialized tool for researchers focused on dissecting the biological roles of specific genes within cellular contexts. These cell lines are derived from well-characterized parental cells in which the target gene, H3C3, has been systematically inactivated using advanced gene-editing techniques, including CRISPR/Cas9 technology. This precise gene knockout allows for the examination of the gene's functional significance in various physiological processes, facilitating a deeper understanding of its role in cell signaling, metabolism, and disease pathogenesis.
The primary mechanism by which H3C3 Gene Knockout Cell Lines operate is through the complete abrogation of gene expression, resulting in the removal of the corresponding protein product. This enables researchers to observe phenotypic changes and cellular responses attributable to the loss of H3C3 function. The implications of this gene knockout extend to diverse fields, including cancer research, regenerative medicine, and therapeutic development, making these cell lines a crucial asset for experimental validation and hypothesis testing.
One of the significant advantages of using H3C3 Gene Knockout Cell Lines is their specificity and reproducibility. Unlike conventional methods such as RNA interference, which may lead to off-target effects, knockout cells provide a robust model that directly correlates the absence of a specific gene with observed biological outcomes. Furthermore, these cell lines are designed for optimal performance across various assays, making them versatile for both in vitro and in vivo studies.
By integrating H3C3 Gene Knockout Cell Lines into research pipelines, scientists can accelerate their discoveries, develop targeted therapies, and contribute to the advancement of personalized medicine. Our company, with a commitment to innovation and quality in biological products, offers these highly characterized cell lines, backed by extensive validation to ensure reliability and efficacy in scientific research.
Please note that all services are for research use only. Not intended for any clinical use.
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