Gene: H3C11
Official Full Name: H3 clustered histone 11provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34243 | H3C11 Knockout cell line (HEK293) | Human | H3C11 | 1:3~1:6 | Negative | Online Inquiry |
H3C11 Gene Knockout Cell Lines are specifically engineered cellular models designed to provide researchers with a powerful tool for the functional analysis of gene expression, regulation, and cellular processes. These cell lines are created using targeted gene editing techniques, such as CRISPR-Cas9, to effectively disrupt the H3C11 gene, allowing for the investigation of gene function and its implications in various biological contexts.
The primary mechanism of action of H3C11 Gene Knockout Cell Lines revolves around the precise deletion of the gene, which facilitates the observation of resultant phenotypic changes and alterations in cellular pathways. This groundbreaking approach provides invaluable insights into gene function and its association with diseases, particularly in cancer and developmental biology, enabling researchers to elucidate the role of H3C11 in pathology and therapeutic responses.
In research and clinical settings, these knockout cell lines stand out due to their capacity to serve as a reliable platform for drug discovery and genetic studies. Researchers can utilize them to screen for novel therapeutic agents, as well as to assess the impact of targeted therapeutics on cell behavior. The availability of H3C11 Gene Knockout Cell Lines thus represents a significant advancement for scientists seeking to model human diseases more accurately and to explore new treatment strategies.
Significantly, these cell lines offer unique advantages over traditional methods, including enhanced specificity, reproducibility, and the ability to generate multiple knockout variants. This versatility empowers researchers to conduct comprehensive experiments with confidence, contributing to a deeper understanding of molecular mechanisms at play.
For researchers, clinicians, and biotechnology professionals, H3C11 Gene Knockout Cell Lines provide a quintessential resource for unraveling complex biological questions and accelerating the journey from bench to bedside. With years of expertise in cell line development and genetic engineering, our company is dedicated to delivering high-quality biological products that meet the rigorous standards of modern scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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