Home / GUF1 Knockout Cell Lines

GUF1 Knockout Cell Lines

Gene: GUF1

Official Full Name: GTP binding elongation factor GUF1provided by HGNC

Gene Summary: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17222 GUF1 Knockout cell line (HeLa) Human GUF1 1:3~1:6 Negative Online Inquiry
KO17223 GUF1 Knockout cell line (HCT 116) Human GUF1 1:2~1:4 Negative Online Inquiry
KO17224 GUF1 Knockout cell line (HEK293) Human GUF1 1:3~1:6 Negative Online Inquiry
KO17225 GUF1 Knockout cell line (A549) Human GUF1 1:3~1:4 Negative Online Inquiry

Background

GUF1 Gene Knockout Cell Lines represent a cutting-edge resource for the study of gene function and protein interactions in mammalian systems. These cell lines have been engineered to have specific deletions in the GUF1 gene, which encodes a mitochondrial GTPase involved in mitochondrial protein synthesis and ribosome biogenesis. By utilizing advanced CRISPR/Cas9 gene-editing technology, these knockout cell lines serve as valuable tools for researchers aiming to dissect the molecular pathways governed by GUF1 and its role in cellular metabolism and disease processes.

The primary mechanism at play in GUF1-knockout cell lines involves the disruption of normal GUF1 function, which subsequently affects mitochondrial efficiency and overall cellular health. This allows researchers to observe phenotypic changes, assess compensatory mechanisms, and develop a deeper understanding of mitochondrial dysfunction, which is implicated in a variety of diseases, including neurodegenerative disorders and metabolic syndromes.

From a scientific perspective, these cell lines hold significant importance in both basic research and clinical applications. They facilitate the investigation of GUF1-dependent biological processes, provide insights into mitochondrial biology, and offer potential pathways for therapeutic interventions targeting GUF1-related conditions. Additionally, these cell lines are invaluable in drug screening assays, allowing researchers to evaluate therapeutic compounds' efficacy in modulating GUF1-associated pathways.

The unique advantage of GUF1 Gene Knockout Cell Lines lies in their precision and the reproducibility of results. Compared to traditional knockout methods, our CRISPR-engineered cell lines afford researchers a reliable, faster, and cost-effective approach to studying gene function. Unlike the reliance on transient transfection methods that often yield variable results, our stable cell lines ensure consistent expression profiles necessary for rigorous scientific inquiry.

In summary, GUF1 Gene Knockout Cell Lines are indispensable for researchers and clinicians looking to explore the complexities of mitochondrial biology. Their potent capabilities to uncover the underlying mechanisms of gene function make them an essential addition to any laboratory focused on genetic research and therapeutic development. Our company, renowned for its commitment to advancing biological research tools, ensures that our products are of the highest quality, supported by extensive scientific validation to meet the needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.