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GSN Knockout Cell Lines

Gene: GSN

Official Full Name: gelsolinprovided by HGNC

Gene Summary: The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37488 GSN Knockout cell line (HeLa) Human GSN 1:3~1:6 Negative Online Inquiry
KO37489 GSN Knockout cell line (HCT 116) Human GSN 1:2~1:4 Negative Online Inquiry
KO37490 GSN Knockout cell line (HEK293) Human GSN 1:3~1:6 Negative Online Inquiry
KO37491 GSN Knockout cell line (A549) Human GSN 1:3~1:4 Negative Online Inquiry

Background

GSN Gene Knockout Cell Lines are sophisticated biological tools designed for the systematic study of the gene encoding gelsolin (GSN), a key actin-regulating protein involved in cell motility, apoptosis, and cytoskeletal dynamics. These cell lines have been genetically engineered to possess a functional knockout of the GSN gene, allowing researchers to assess the downstream effects of GSN depletion on cellular behavior, signaling pathways, and disease mechanisms. By utilizing targeted CRISPR/Cas9 technology, these cell lines ensure precise gene editing, leading to reproducible and reliable experimental outcomes.

The primary function of GSN Gene Knockout Cell Lines is to provide a platform for understanding the role of GSN in various biological processes, including cell movement, wound healing, and cancer metastasis. In vitro studies utilizing these knockout cell lines can reveal critical insights into the molecular underpinnings of these processes, paving the way for novel therapeutic strategies targeting actin dynamics.

Scientifically, the importance of GSN knockout models lies in their broad applications in academic and clinical research, particularly in cancer biology, neurobiology, and developmental studies. They allow for the exploration of gene function in relevant contexts, enhancing the understanding of cellular responses to various stimuli or drug treatments.

Compared to alternative models, such as transient knockdown with siRNA or less specific knockout systems, GSN Gene Knockout Cell Lines provide durability and stability, allowing for long-term experiments and the generation of reproducible data. Researchers benefit from their rigorously validated performance, ensuring that findings can be reliably attributed to the absence of GSN.

For researchers and clinicians, the availability of GSN Gene Knockout Cell Lines opens new avenues for innovation in therapeutic development and biomolecular research, facilitating groundbreaking discoveries in the field.

Our company's extensive expertise in gene editing technologies and commitment to advancing scientific research underscores the quality and reliability of our offerings, ensuring that your research is built on a solid foundation.

Please note that all services are for research use only. Not intended for any clinical use.

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