Gene: GPR161
Official Full Name: G protein-coupled receptor 161provided by HGNC
Gene Summary: The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10055 | GPR161 Knockout cell line (HeLa) | Human | GPR161 | 1:3~1:6 | Negative | Online Inquiry |
KO10056 | GPR161 Knockout cell line (HCT 116) | Human | GPR161 | 1:2~1:4 | Negative | Online Inquiry |
KO10057 | GPR161 Knockout cell line (HEK293) | Human | GPR161 | 1:3~1:6 | Negative | Online Inquiry |
KO10058 | GPR161 Knockout cell line (A549) | Human | GPR161 | 1:3~1:4 | Negative | Online Inquiry |
GPR161 Gene Knockout Cell Lines represent a cutting-edge suite of tools designed for advanced genetic research and therapeutic investigations. GPR161, a G protein-coupled receptor (GPCR), plays a crucial role in a variety of cellular processes, including signal transduction and cell fate determination. By utilizing gene knockout technology, these cell lines enable researchers to elucidate the functions of GPR161 by observing the resultant phenotypic changes arising from the absence of the receptor. This innovative approach facilitates the examination of GPR161's involvement in vital biological pathways, especially those related to neurodevelopment and oncogenesis.
The key mechanism of action for GPR161 gene knockout cell lines is the targeted disruption of the GPR161 gene, accomplished through advanced genome editing techniques such as CRISPR-Cas9 or homologous recombination. This targeted approach not only allows for precise deletions but also minimizes off-target effects, thereby ensuring the reliability of experimental outcomes. Researchers can leverage these cell lines to investigate the gene's contributions to signaling cascades and its potential role in various diseases, thus opening new avenues for drug discovery and therapeutic intervention.
The scientific importance of the GPR161 gene knockout cell lines extends beyond basic research; they have significant applications in translational medicine, particularly in the fields of cancer research and developmental biology. With the growing recognition of the role of GPCRs in numerous pathologies, understanding GPR161's functions can lead to breakthroughs in developing targeted treatments for conditions such as glioma or neurodevelopmental disorders.
Compared to conventional research tools, GPR161 gene knockout cell lines offer distinct advantages, including enhanced specificity and reduced experimental variability. Unlike traditional pharmacological approaches that manipulate receptor activity, these cell lines enable detailed dissection of GPR161-related pathways without the confounding effects of receptor agonists or antagonists. This precision is invaluable, positioning the product as a uniquely powerful option for researchers needing rigorous and reproducible data.
For researchers, clinicians, and pharmaceutical developers, the GPR161 gene knockout cell lines represent a pivotal resource that can expedite discovery and enhance understanding of critical biological processes. As leaders in the field of genetic engineering, our company prides itself on delivering high-quality, customizable cell line solutions that empower the scientific community to drive innovation forward.
Please note that all services are for research use only. Not intended for any clinical use.
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