Gene: GPER1
Official Full Name: G protein-coupled estrogen receptor 1provided by HGNC
Gene Summary: This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37531 | GPER1 Knockout cell line (HCT 116) | Human | GPER1 | 1:2~1:4 | Negative | Online Inquiry |
KO37532 | GPER1 Knockout cell line (HEK293) | Human | GPER1 | 1:3~1:6 | Negative | Online Inquiry |
GPER1 Gene Knockout Cell Lines are innovative research tools designed for the in-depth study of the G-protein coupled estrogen receptor 1 (GPER1), which plays a critical role in various physiological processes, including hormone signaling and cell differentiation. By employing the CRISPR-Cas9 gene-editing technology, these cell lines have been engineered to harbor specific gene deletions that facilitate the examination of GPER1’s function and its downstream effects on cellular pathways. The knockout mechanism ensures that researchers can obtain insights into the receptor’s biological roles without the interference of wild-type variations, allowing for a clearer understanding of estrogen signaling.
The scientific importance of GPER1 Gene Knockout Cell Lines is profound, as they provide an invaluable resource for investigations into diseases influenced by estrogen, such as hormone-dependent cancers and metabolic disorders. Their application in both in vitro and in vivo studies enhances the potential for breakthrough discoveries in drug development, personalized medicine, and therapeutic interventions targeting estrogen receptors.
Compared to conventional cell lines, these knockout models present unique advantages such as heightened specificity and reproducibility in experimental results, significantly reducing confounding variables that can obscure data interpretation. Researchers benefit from the efficiency and precision of CRISPR technology, rendering them a superior choice for dissecting complex signaling networks influenced by GPER1.
For researchers and clinicians committed to advancing the understanding of estrogen-related pathways, GPER1 Gene Knockout Cell Lines offer an essential tool for driving innovation and discovery. Our company prides itself on delivering high-quality, validated biological products with unwavering commitment to scientific excellence, empowering the scientific community to unravel the complexities of cellular mechanisms related to human health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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