Gene: GPAT4
Official Full Name: glycerol-3-phosphate acyltransferase 4provided by HGNC
Gene Summary: Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26343 | GPAT4 Knockout cell line (HeLa) | Human | GPAT4 | 1:3~1:6 | Negative | Online Inquiry |
KO26344 | GPAT4 Knockout cell line (HCT 116) | Human | GPAT4 | 1:2~1:4 | Negative | Online Inquiry |
KO26345 | GPAT4 Knockout cell line (HEK293) | Human | GPAT4 | 1:3~1:6 | Negative | Online Inquiry |
KO26346 | GPAT4 Knockout cell line (A549) | Human | GPAT4 | 1:3~1:4 | Negative | Online Inquiry |
GPAT4 Gene Knockout Cell Lines represent a cutting-edge tool in cellular and molecular biology, designed to facilitate the in-depth study of glycerol-3-phosphate acyltransferase 4 (GPAT4) functional mechanisms. Due to its role in lipid metabolism, GPAT4 is crucial for the regulation of energy homeostasis and the synthesis of triacylglycerols. These knockout cell lines are engineered to have the GPAT4 gene completely disabled, allowing researchers to investigate the downstream effects on cellular metabolism and the broader implications for various metabolic disorders.
The primary function of GPAT4 is to catalyze the initial step in the glycerolipid biosynthesis pathway, influencing lipid droplet formation and energy storage. By using GPAT4 knockout cell lines, scientists can elucidate the involvement of GPAT4 in metabolic pathways, assess alterations in lipid profiles, and evaluate the potential compensatory mechanisms activated in its absence. This specificity makes these cell lines a valuable asset for research on obesity, diabetes, and cardiovascular diseases.
In research and clinical settings, the GPAT4 knockout cell lines serve as significant models for testing therapeutic compounds aimed at modulating lipid metabolism. The insights gained from studies using these cells can lead to the development of targeted therapies for metabolic diseases characterized by dysregulated lipid storage and mobilization.
What sets our GPAT4 Gene Knockout Cell Lines apart from alternative products is their high fidelity and reproducibility, achieved through rigorous screening and validation processes. Unlike less specific products, our cell lines ensure a consistent genetic background, encompassing a broad range of applications in drug discovery and fundamental research.
For researchers and clinicians, the ability to work with such tailored models simplifies the investigation of GPAT4-related pathways, enhances translational potential, and encourages innovation in tackling challenging metabolic issues. Our company brings years of expertise in creating precise biological models, ensuring that our GPAT4 Gene Knockout Cell Lines are not only reliable but also a cornerstone for future scientific advancements in the field of lipid metabolism and beyond.
Please note that all services are for research use only. Not intended for any clinical use.
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