GP1BB Knockout Cell Lines

Gene: GP1BB

Official Full Name: glycoprotein Ib platelet subunit betaprovided by HGNC

Gene Summary: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO04405	GP1BB Knockout cell line (HEK293)	Human	GP1BB	1:3~1:6	Negative	Online Inquiry

Background

GP1BB Gene Knockout Cell Lines are a cutting-edge biological tool developed for researchers studying the intricate mechanisms of cellular function, signaling pathways, and gene regulation. These cell lines are engineered to lack the GP1BB gene, a critical component implicated in platelet activation and blood coagulation processes. By utilizing CRISPR-Cas9 technology, the GP1BB Gene Knockout Cell Lines facilitate precise gene editing, enabling researchers to dissect the role of GP1BB in pathophysiological conditions such as thrombosis and certain hematological disorders.

The primary function of GP1BB is to encode a subunit of the glycoprotein complex involved in platelet aggregation. Knockout of this gene leads to a decreased ability of platelets to aggregate in response to stimuli, providing a valuable model for investigating the underlying mechanisms of platelet function or dysfunction. Researchers can leverage these knockout lines in various assays, including platelet aggregation studies, apoptosis assays, and drug response evaluations, making them indispensable for advancing our understanding of hematology and cardiovascular medicine.

In clinical and research settings, the utility of GP1BB Gene Knockout Cell Lines extends to translational studies that can inform therapeutic strategies for managing thrombotic diseases. The unique ability to model the effects of GP1BB deficiency allows for targeted therapeutic intervention and drug development, paving the way for novel treatments.

Compared to other genetic models, the GP1BB Gene Knockout Cell Lines offer precise gene editing, reduced off-target effects, and a reliable background for experimentation, making them superior tools for genetic studies. Their established lineage ensures consistent results across experiments, a critical factor for validating scientific hypotheses.

For researchers and clinicians focused on unraveling the complexities of platelet biology and improving therapeutic outcomes, adopting GP1BB Gene Knockout Cell Lines represents a strategic investment in high-quality, reproducible research. Backed by our extensive expertise in genetic engineering and cellular biology, we pride ourselves on providing innovative solutions that empower scientists in their quests for discovery and advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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