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GNA11 Knockout Cell Lines

Gene: GNA11

Official Full Name: G protein subunit alpha 11provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08056 GNA11 Knockout cell line (HeLa) Human GNA11 1:3~1:6 Negative Online Inquiry
KO08057 GNA11 Knockout cell line (HCT 116) Human GNA11 1:2~1:4 Negative Online Inquiry
KO08058 GNA11 Knockout cell line (HEK293) Human GNA11 1:3~1:6 Negative Online Inquiry
KO08059 GNA11 Knockout cell line (A549) Human GNA11 1:3~1:4 Negative Online Inquiry

Background

GNA11 Gene Knockout Cell Lines are specialized cellular models engineered to lack the GNA11 gene, which encodes a key regulator protein involved in G protein-coupled receptor signaling pathways. By creating these knockout models, researchers can effectively study the functional consequences of GNA11 loss, offering insight into various physiological processes and disease mechanisms, particularly in oncological and neurological contexts.

The primary function of GNA11 gene knockout cell lines lies in their ability to disrupt the normal signaling cascades associated with GNA11. This disruption can elucidate the role of GNA11 in cell proliferation, differentiation, and apoptosis, allowing scientists to investigate how alterations in GNA11 activity contribute to diseases such as cancer and metabolic disorders. The mechanisms through which these cell lines operate serve as a powerful tool for modeling human diseases, enabling researchers to evaluate the therapeutic potential of targeted treatments and elucidate the intricate networks governing cellular responses.

In the realm of scientific research and clinical applications, GNA11 gene knockout cell lines prove invaluable. They serve as models for drug discovery and development, enabling researchers to explore the therapeutic efficacy of novel agents targeting G protein signaling pathways. Such investigations are particularly significant given the increasing recognition of the role that aberrant G-protein signaling plays in cancer and other pathologies.

Compared to traditional cell lines that still express the GNA11 gene, our GNA11 gene knockout models offer distinct advantages, such as high specificity in signaling studies and reduced background noise. This specificity enhances experimental accuracy and the quality of data generated, making them essential for researchers striving for precision in their studies.

Furthermore, these cell lines support a wide range of applications, from basic research to translational studies, making them a versatile addition to any laboratory focused on molecular biology, pharmacology, or cancer research. With a commitment to scientific innovation and quality, our company is dedicated to providing advanced cell line solutions that empower researchers and clinicians to push the boundaries of biological discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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