Gene: GMPPA
Official Full Name: GDP-mannose pyrophosphorylase Aprovided by HGNC
Gene Summary: This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26933 | GMPPA Knockout cell line (HeLa) | Human | GMPPA | 1:3~1:6 | Negative | Online Inquiry |
KO26934 | GMPPA Knockout cell line (HCT 116) | Human | GMPPA | 1:2~1:4 | Negative | Online Inquiry |
KO26935 | GMPPA Knockout cell line (HEK293) | Human | GMPPA | 1:3~1:6 | Negative | Online Inquiry |
KO26936 | GMPPA Knockout cell line (A549) | Human | GMPPA | 1:3~1:4 | Negative | Online Inquiry |
GMPPA Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate the functional study of the GMPPA gene, crucial for various biological processes, including cellular metabolism and glycosylation pathways. Gene knockout techniques leverage targeted genome editing technologies, such as CRISPR/Cas9, to induce specific deletions within the GMPPA gene, thereby producing cell lines that no longer express the corresponding protein. This enables researchers to explore the effects of GMPPA loss on cellular behavior, signaling pathways, and overall cellular health.
The key functions of these knockout cell lines lie in their ability to mimic pathological conditions and investigate disease mechanisms, particularly in disorders related to glycoprotein metabolism. By understanding the role of GMPPA at a molecular level, researchers can unravel its implications in conditions like immunodeficiency, cancer, and developmental abnormalities. These models are particularly significant for drug discovery and development, providing insights into how inhibiting or restoring GMPPA function may alter disease phenotypes.
One of the standout advantages of GMPPA Gene Knockout Cell Lines lies in their specificity and reliability compared to alternative models. Conventional methods, such as chemical inhibitors or transient RNA interference, often lack the precision and long-term stability that knockout cell lines provide. Researchers can conduct prolonged studies with consistent results, fostering reproducibility in experimental outcomes.
Moreover, these cell lines accommodate various applications, including high-throughput screening and functional genomics, offering researchers a robust platform for innovation. The ability to compare wild-type and knockout lines allows for direct assessments of GMPPA's role in cellular functions and disease mechanisms, proving invaluable in both academic and clinical research environments.
Our company prides itself on its expertise in developing high-quality genetic tools and cell lines. With a commitment to advancing scientific research, we provide not only GMPPA Gene Knockout Cell Lines but also comprehensive support and resources to ensure that our products meet the rigorous demands of modern biological research. Researchers can trust our offerings for their precision, reliability, and contributions to the understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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