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GMIP Knockout Cell Lines

Gene: GMIP

Official Full Name: GEM interacting proteinprovided by HGNC

Gene Summary: This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22731 GMIP Knockout cell line (HeLa) Human GMIP 1:3~1:6 Negative Online Inquiry
KO22732 GMIP Knockout cell line (HCT 116) Human GMIP 1:2~1:4 Negative Online Inquiry
KO22733 GMIP Knockout cell line (HEK293) Human GMIP 1:3~1:6 Negative Online Inquiry
KO22734 GMIP Knockout cell line (A549) Human GMIP 1:3~1:4 Negative Online Inquiry

Background

GMIP Gene Knockout Cell Lines are precisely engineered mammalian cell lines in which the GMIP (GTPase activating protein for rac) gene has been systematically inactivated through targeted gene knockout techniques. These cell lines are essential tools for studying the functional roles of GMIP in cellular processes, such as signal transduction, cytoskeletal dynamics, and cell proliferation. By removing the GMIP gene, researchers can investigate the phenotypic effects and underlying mechanisms associated with its absence, enabling a deeper understanding of its contributions to various physiological and pathological conditions.

The key function of GMIP Gene Knockout Cell Lines lies in their ability to facilitate the study of GTPase signaling pathways, particularly those involving Rho family proteins. GMIP regulates the activity of these GTPases, and by utilizing knockout cell lines, scientists can elucidate the cascades of cellular events triggered by GMIP modulation. This understanding has significant implications not only for basic biological research but also for the development of therapeutic strategies targeting diseases related to aberrant GTPase signaling, including cancer and neurodegenerative disorders.

The scientific importance of GMIP Gene Knockout Cell Lines extends to their application in drug discovery and functional genomics. They allow for high-throughput screening of potential therapeutic compounds that may affect GMIP-related pathways, offering researchers a powerful platform to identify novel drug candidates. Moreover, these cell lines provide an excellent model for validating biological hypotheses and dissecting complex cellular interactions.

Compared to conventional cell lines, GMIP Gene Knockout Cell Lines provide a highly specific and targeted approach to studying the gene's functions. Unlike transient knockdown methods that may lead to incomplete inhibition or compensatory effects, these knockout lines offer reproducibility and stability essential for rigorous experimental designs. Their availability saves researchers valuable time and resources while enhancing the reliability of experimental outcomes.

In conclusion, GMIP Gene Knockout Cell Lines represent a valuable resource for researchers and clinicians alike, providing unprecedented insights into the cellular roles of GMIP. This product is designed to empower scientific discoveries and foster innovative approaches to understanding GMIP’s implications in health and disease. Our company specializes in the development of high-quality biological products, leveraging advanced genetic engineering techniques to provide researchers with the tools necessary to advance their work in molecular and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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