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GLRX5 Knockout Cell Lines

Gene: GLRX5

Official Full Name: glutaredoxin 5provided by HGNC

Gene Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22854 GLRX5 Knockout cell line (HeLa) Human GLRX5 1:3~1:6 Negative Online Inquiry
KO22855 GLRX5 Knockout cell line (HCT 116) Human GLRX5 1:2~1:4 Negative Online Inquiry
KO22856 GLRX5 Knockout cell line (HEK293) Human GLRX5 1:3~1:6 Negative Online Inquiry
KO22857 GLRX5 Knockout cell line (A549) Human GLRX5 1:3~1:4 Negative Online Inquiry

Background

GLRX5 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the GLRX5 gene, which encodes for a vital mitochondrial protein involved in redox homeostasis and iron-sulfur cluster assembly. By creating these knockout lines, researchers can investigate the functional roles of GLRX5 in cellular metabolism, oxidative stress response, and overall mitochondrial health. The absence of this gene allows for a clearer understanding of its implications in various pathophysiological conditions, including neurodegenerative diseases and cancer.

The primary function of GLRX5 is to maintain mitochondrial integrity and function by participating in antioxidant defense mechanisms. In knockout models, the disrupted expression of GLRX5 elucidates the downstream effects of impaired mitochondrial activity, thus serving as a crucial tool in unraveling the complexities of cell signaling pathways related to oxidative stress and metabolic regulation.

These cell lines hold significant importance in both research and clinical settings, particularly in studies focused on mitochondrial dysfunction and related diseases. They provide a platform for high-throughput screening of potential therapeutic compounds, detailed investigations into mitochondrial biogenesis, and assessments of cellular response to various stressors.

One of the key advantages of GLRX5 Gene Knockout Cell Lines is their specificity and reproducibility, allowing for precise control and manipulation in experimental designs, which are essential for robust data interpretation. Unlike other knockout models that may affect multiple pathways, our GLRX5 knockout lines are tailored to give researchers exactly the insights they need without unwanted variables.

Given the increasing recognition of mitochondrial health as a cornerstone in understanding diseases, the GLRX5 Gene Knockout Cell Lines are invaluable for scientists seeking to explore new therapeutic avenues. Their unique selling points—including detailed characterization, validated effectiveness, and ease of use—make them a preferred choice for researchers aiming for high-impact results.

As a leader in the field of biological products, we are committed to providing cutting-edge tools that facilitate groundbreaking discoveries. Our expertise in gene editing technologies ensures that our GLRX5 Gene Knockout Cell Lines meet the highest research standards, ultimately empowering the scientific community in advancing human health.

Please note that all services are for research use only. Not intended for any clinical use.

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