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GLRX3 Knockout Cell Lines

Gene: GLRX3

Official Full Name: glutaredoxin 3provided by HGNC

Gene Summary: This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31739 GLRX3 Knockout cell line (HeLa) Human GLRX3 1:3~1:6 Negative Online Inquiry
KO31740 GLRX3 Knockout cell line (HCT 116) Human GLRX3 1:2~1:4 Negative Online Inquiry
KO31741 GLRX3 Knockout cell line (HEK293) Human GLRX3 1:3~1:6 Negative Online Inquiry
KO31742 GLRX3 Knockout cell line (A549) Human GLRX3 1:3~1:4 Negative Online Inquiry

Background

GLRX3 Gene Knockout Cell Lines are specialized cellular models designed to facilitate in-depth studies of the GLRX3 gene, a critical component in redox signaling and thiol metabolism. By employing CRISPR-Cas9 technology, these cell lines have had the GLRX3 gene specifically disabled, enabling researchers to investigate its functional roles in cellular processes, particularly those associated with oxidative stress response and mitochondrial function.

The primary mechanism of these knockout cell lines lies in their ability to allow for the observation of phenotypic changes arising from the loss of the GLRX3 gene. Researchers can assess how the absence of GLRX3 influences susceptibility to oxidative damage, alterations in cellular metabolism, and the overall impact on cell viability and proliferation. This knowledge can be invaluable for understanding various pathophysiological conditions where redox dysregulation plays a role, such as cancer, neurodegeneration, and cardiovascular diseases.

In research and clinical settings, GLRX3 Gene Knockout Cell Lines have significant implications for drug discovery and development, as they provide a platform for screening potential therapeutic agents targeting oxidative stress-related pathways. Furthermore, they can enhance the understanding of gene interactions and the mechanisms underlying disease progression, thus offering insights that are often unattainable through conventional methods.

Unique advantages of GLRX3 Gene Knockout Cell Lines compared to alternative models include their precise genome editing, which leads to robust, reproducible results, and the versatility to be utilized in various cellular contexts. Unlike traditional knockdown approaches, which may yield incomplete or transient gene silencing, knockout cell lines offer a definitive and permanent loss of function, thereby presenting a clearer picture of gene activity.

The value of GLRX3 Gene Knockout Cell Lines to researchers and clinicians is evident in their capacity to unlock new avenues of exploration in redox biology and pharmacology. By allowing for comprehensive analysis of GLRX3-related pathways, these models equip scientists with the tools necessary to drive innovative research and find impactful solutions for oxidative-stress-related diseases.

Our company specializes in providing cutting-edge biological products, such as GLRX3 Gene Knockout Cell Lines, backed by rigorous quality control and extensive scientific support. We are committed to advancing research capabilities and enabling discoveries that pave the way for future therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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