Gene: GLRX2
Official Full Name: glutaredoxin 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05686 | GLRX2 Knockout cell line (HeLa) | Human | GLRX2 | 1:3~1:6 | Negative | Online Inquiry |
KO05687 | GLRX2 Knockout cell line (HCT 116) | Human | GLRX2 | 1:2~1:4 | Negative | Online Inquiry |
KO05688 | GLRX2 Knockout cell line (HEK293) | Human | GLRX2 | 1:3~1:6 | Negative | Online Inquiry |
KO05689 | GLRX2 Knockout cell line (A549) | Human | GLRX2 | 1:3~1:4 | Negative | Online Inquiry |
GLRX2 Gene Knockout Cell Lines are specialized cultured cells in which the GLRX2 gene has been effectively inactivated or "knocked out." This gene encodes for Glutaredoxin 2, an essential protein involved in cellular redox signaling and maintaining glutathione homeostasis. The key function of GLRX2 is to contribute to cellular defense against oxidative stress and regulate crucial signaling pathways. By using CRISPR-Cas9 technology or other precise gene-editing techniques, these knockout cell lines enable researchers to investigate the functional role of GLRX2 in various biological processes, such as apoptosis, proliferation, and response to oxidative stress.
The scientific importance of GLRX2 Gene Knockout Cell Lines lies in their applicability in both research and clinical settings. Researchers can use these models to study the implications of GLRX2 deficiency in diseases characterized by oxidative stress, including neurodegenerative disorders, cancer, and metabolic syndromes. Moreover, they facilitate the investigation into therapeutic target validation and the potential development of antioxidants for treatment strategies.
One of the distinctive advantages of our GLRX2 Gene Knockout Cell Lines is their ready-to-use nature, allowing researchers to save valuable time that would otherwise be spent on generating knockout models from scratch. This product offers consistency and reproducibility in experiments where GLRX2 involvement is being examined, ensuring high-quality data generation. Unlike other alternatives, our cell lines have undergone rigorous validation, providing confidence in their genetic modification and functional status.
For researchers and clinicians focused on oxidative stress responses and related diseases, these knockout cell lines represent an invaluable resource for exploring innovative therapeutic pathways and understanding pathophysiological mechanisms in greater depth. Our company specializes in the development of advanced biological models, and we bring a wealth of expertise in cell line engineering and characterization, guaranteeing that our products meet the highest scientific standards.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.