Gene: GFI1
Official Full Name: growth factor independent 1 transcriptional repressorprovided by HGNC
Gene Summary: This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03491 | GFI1 Knockout cell line (HCT 116) | Human | GFI1 | 1:2~1:4 | Negative | Online Inquiry |
KO03492 | GFI1 Knockout cell line (HEK293) | Human | GFI1 | 1:3~1:6 | Negative | Online Inquiry |
GFI1 Gene Knockout Cell Lines are genetically modified cellular models specifically designed to facilitate the study of the GFI1 gene, which plays a pivotal role in hematopoiesis and lymphocyte differentiation. These cell lines have been engineered using sophisticated CRISPR/Cas9 technology to ablate the expression of the GFI1 gene, allowing researchers to observe and investigate the precise biological impacts of its loss. By disabling GFI1, these cell lines create an unprecedented opportunity to analyze pathways involved in immune development and various hematological disorders.
Key functions of the GFI1 Gene Knockout Cell Lines include the ability to mimic conditions relevant to the investigation of GFI1-associated pathologies, such as lymphoid leukemia and immune deficiencies. By examining the alterations in cellular behavior and gene expression profiles in these knockout models, researchers can garner insights into the mechanistic role of GFI1 in various cellular contexts. Furthermore, these cell lines are instrumental in drug discovery and therapeutic targeting, enabling high-throughput screening and validation of potential interventions.
The scientific importance of GFI1 Gene Knockout Cell Lines cannot be overstated, as they not only provide a valuable in vitro system for studying the ramifications of GFI1 loss but also bridge gaps in understanding the molecular underpinnings of related diseases. Compared to conventional models, these knockout lines offer enhanced specificity, reproducibility, and the ability to conduct experiments in a controlled manner.
For researchers and clinicians, the clear advantages of utilizing GFI1 Gene Knockout Cell Lines lie in their reliable performance and the depth of biological insight they provide. In contrast to other models that may not accurately reflect the absence of GFI1 activity, our knockout lines ensure consistent and relevant experimental outcomes, which is critical for advancing research in hematological health.
Our company specializes in the development and provision of high-quality genetic materials and cell lines, backed by extensive expertise in molecular biology and genetics. We are committed to empowering the scientific community with innovative solutions that facilitate groundbreaking research and pave the way for potential clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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