Gene: GDF7
Official Full Name: growth differentiation factor 7provided by HGNC
Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08501 | GDF7 Knockout cell line (HEK293) | Human | GDF7 | 1:3~1:6 | Negative | Online Inquiry |
GDF7 Gene Knockout Cell Lines are genetically engineered cell lines that have been modified to disrupt the expression of the Growth Differentiation Factor 7 (GDF7) gene. This product allows researchers to explore the functional role of GDF7 in various biological processes, including bone and cartilage development, as well as its involvement in muscle maintenance and regeneration. By using targeted gene knockout strategies, scientists can elucidate the gene's specific contributions to different cellular pathways and disease mechanisms, enhancing our understanding of developmental biology and related fields.
The core mechanism of these knockout cell lines involves CRISPR-Cas9 technology or other gene-editing techniques, which enable precise deletion or alteration of the GDF7 gene. This targeted approach facilitates in-depth analysis of gene function and downstream effects on signaling pathways, cellular differentiation, and tissue regeneration. The ability to study GDF7 in a controlled environment provides vital insights into its potential roles in pathologies such as osteoarthritis and muscular dystrophies.
Scientifically, GDF7 Gene Knockout Cell Lines hold immense importance for applications in both research and clinical settings. They serve as powerful models for drug development and validation, allowing for the screening of therapeutic targets aimed at modulating GDF7 signaling. Moreover, these cell lines are invaluable in studies assessing responses to various treatments, providing a foundation for understanding how genetic variations influence therapeutic efficacy.
Compared to alternative products, GDF7 Gene Knockout Cell Lines offer a unique combination of specificity, reliability, and ease of use. Traditional techniques, such as chemical inhibitors or non-targeted shRNA, often lack precision and can produce confounding results. Our knockout cell lines eliminate unwanted off-target effects, giving researchers greater confidence in their experimental outcomes.
For researchers and clinicians alike, the value of GDF7 Gene Knockout Cell Lines lies in their capacity to accelerate discoveries in the fields of developmental biology, genetics, and regenerative medicine. By providing a more accurate model of GDF7 function, these cell lines empower users to derive meaningful conclusions and potentially pave the way for novel therapeutic interventions.
With years of expertise in biotechnology and a commitment to quality, our company specializes in delivering advanced genetic products tailored to meet the evolving needs of the scientific community. Choose GDF7 Gene Knockout Cell Lines to enhance your research and unlock the full potential of gene study today.
Please note that all services are for research use only. Not intended for any clinical use.
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