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GCA Knockout Cell Lines

Gene: GCA

Official Full Name: grancalcinprovided by HGNC

Gene Summary: This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28805 GCA Knockout cell line (HeLa) Human GCA 1:3~1:6 Negative Online Inquiry
KO28806 GCA Knockout cell line (HCT 116) Human GCA 1:2~1:4 Negative Online Inquiry
KO28807 GCA Knockout cell line (HEK293) Human GCA 1:3~1:6 Negative Online Inquiry
KO28808 GCA Knockout cell line (A549) Human GCA 1:3~1:4 Negative Online Inquiry

Background

GCA Gene Knockout Cell Lines are genetically modified cellular models that have undergone precise gene knockout procedures to eliminate specific genes of interest, allowing researchers to study the phenotypic consequences of gene loss in a controlled environment. This innovative product employs CRISPR/Cas9 technology or similar gene-editing techniques to achieve high fidelity and specificity in gene disruption. Each cell line is meticulously validated to ensure the complete absence of the targeted gene, which is critical for experimental reproducibility and accuracy.

The primary function of GCA Gene Knockout Cell Lines lies in their ability to elucidate gene function, enabling investigations into various biological pathways, disease mechanisms, and therapeutic targets. By comparing the knockout lines to their wild-type counterparts, researchers can discern how the absence of specific genes affects cellular behavior, signaling pathways, and overall phenotype, thereby contributing to a deeper understanding of genetic contributions to health and disease.

In the realm of scientific research and clinical applications, these cell lines are invaluable tools for studying genetic disorders, cancer biology, drug resistance, and therapeutic interventions. The capability to create disease-specific models accelerates the development of targeted therapies and personalized medicine approaches, which are increasingly relevant in today's healthcare landscape.

Compared to alternative models such as overexpression systems or transient knockdown strategies, GCA Gene Knockout Cell Lines offer robust, long-term gene silencing, which enhances the reliability of experimental outcomes. Furthermore, the availability of a range of knockout cell lines across various tissues and species makes this product highly adaptable for diverse research needs.

Researchers and clinicians can benefit significantly from GCA Gene Knockout Cell Lines, as they provide a platform for groundbreaking discoveries that stimulate innovation in gene therapy, regenerative medicine, and drug development. The precise knockout capability helps streamline experiments aimed at identifying novel biomarkers and therapeutic targets, thereby improving the efficiency of research programs.

With a proven track record in the field of genetic engineering, our company is committed to supporting scientific advancement through high-quality biological products. Our expertise ensures that each GCA Gene Knockout Cell Line is comprehensively characterized and ready to drive impactful research and clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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