Gene: GAPDHS
Official Full Name: glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by HGNC
Gene Summary: This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28119 | GAPDHS Knockout cell line (HEK293) | Human | GAPDHS | 1:3~1:6 | Negative | Online Inquiry |
GAPDHS Gene Knockout Cell Lines represent a critical advancement in cellular biology, specifically designed for the study of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) enzyme. These cell lines are genetically engineered to exhibit a complete knockout of the GAPDHS gene, which encodes a vital enzyme involved in glycolysis and various metabolic pathways. By eliminating GAPDHS expression, these cell lines serve as a powerful model for investigating the regulatory roles of this enzyme in cellular processes and disease mechanisms.
The key function of the GAPDHS Gene Knockout Cell Lines lies in their ability to facilitate in-depth studies into the effects of GAPDHS deficiency on cellular metabolism, proliferation, and differentiation. By comparing these knockout lines with wild-type counterparts, researchers can unravel the intricate pathways that GAPDHS influences, offering insights into its role in areas such as cancer biology, reproductive health, and metabolic disorders. This makes the cell lines invaluable in both basic research and potential translational applications.
Scientifically, the importance of these knockout cell lines cannot be overstated; they provide a unique platform to dissect the function of GAPDHS in physiological and pathological conditions. This has significant implications for drug discovery and the development of therapeutic strategies aimed at targeting metabolic diseases or enhancing fertility outcomes.
Compared to conventional cell models, GAPDHS Gene Knockout Cell Lines offer distinct advantages, including the specificity of gene disruption and the ability to mimic human disease states more accurately. Their robust nature allows for consistent experimental results, which researchers often struggle to achieve with less defined systems.
Researchers and clinicians can significantly benefit from utilizing these knockout cell lines as they bridge the gap between basic science and clinical application. The insights gained from studies using these models have the potential to inform clinical approaches and influence treatment protocols.
With a strong commitment to innovation and excellence, our company specializes in providing high-quality biological products like the GAPDHS Gene Knockout Cell Lines, backed by extensive expertise in genetic engineering and cell line development. This enables us to deliver cutting-edge tools that empower researchers to advance their studies and clinical endeavors effectively.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.