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GALNT10 Knockout Cell Lines

Gene: GALNT10

Official Full Name: polypeptide N-acetylgalactosaminyltransferase 10provided by HGNC

Gene Summary: This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17485 GALNT10 Knockout cell line (HeLa) Human GALNT10 1:3~1:6 Negative Online Inquiry
KO17486 GALNT10 Knockout cell line (HCT 116) Human GALNT10 1:2~1:4 Negative Online Inquiry
KO17487 GALNT10 Knockout cell line (HEK293) Human GALNT10 1:3~1:6 Negative Online Inquiry
KO17488 GALNT10 Knockout cell line (A549) Human GALNT10 1:3~1:4 Negative Online Inquiry

Background

GALNT10 Gene Knockout Cell Lines are specifically engineered cellular models that have had the GALNT10 gene inactivated, providing researchers with powerful tools for studying the biological roles of this gene in various physiological and pathological contexts. The GALNT10 gene encodes a member of the polypeptide N-acetylgalactosaminyltransferase family, which is involved in the modification of proteins through O-glycosylation, a crucial post-translational modification that affects protein stability, signaling, and interactions.

The distinctive function of GALNT10 knockout cell lines allows scientists to investigate the impact of O-glycosylation on cellular processes such as cell adhesion, migration, and signaling pathways. By examining these knockout lines, researchers can elucidate the role of GALNT10 in diseases like cancer, where abnormal glycosylation patterns are often observed. These models also facilitate high-throughput screening of potential therapeutic compounds targeting pathways influenced by GALNT10.

Comparatively, GALNT10 knockout cell lines provide specific advantages over wild-type cell lines or transient knockdown approaches, which may not provide a stable or consistent genetic modification. The knockout lines offer a controllable environment for reproducible results, making them invaluable for longitudinal studies and drug discovery efforts.

For researchers and clinicians, the utilization of GALNT10 knockout cell lines translates to more reliable data and insights into the functional genomics of glycosylation, allowing for advances in therapeutic strategies. Our company boasts extensive expertise in the development of cutting-edge genetic models, ensuring our products meet the highest standards of quality and scientific integrity, ultimately empowering researchers to make significant discoveries in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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