Gene: GAL3ST1
Official Full Name: galactose-3-O-sulfotransferase 1provided by HGNC
Gene Summary: Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33166 | GAL3ST1 Knockout cell line (HEK293) | Human | GAL3ST1 | 1:3~1:6 | Negative | Online Inquiry |
KO33167 | GAL3ST1 Knockout cell line (A549) | Human | GAL3ST1 | 1:3~1:4 | Negative | Online Inquiry |
GAL3ST1 Gene Knockout Cell Lines are sophisticated biological tools designed for researchers investigating the role of the GAL3ST1 gene, which encodes an enzyme involved in the sulfation of glycosaminoglycans. By creating a functional knockout of this gene, these cell lines allow scientists to explore the downstream effects of GAL3ST1 deficiency, offering insights into various biological processes, including cellular signaling, development, and disease mechanisms.
The primary function of GAL3ST1 Gene Knockout Cell Lines is to facilitate the study of galactose-3-sulfotransferase-1 (GAL3ST1) in a controlled laboratory setting. These cell lines operate by disrupting the expression of the GAL3ST1 gene, which hinders the synthesis of specific sulfated polysaccharides. Researchers can utilize these cell lines to investigate the impact of GAL3ST1 absence on cellular behavior, including proliferation, differentiation, and response to external stimuli, thus uncovering critical insights into the gene's role in genetic disorders, cancer biology, and regenerative medicine.
The scientific importance of these knockout cell lines extends to their applications in both research and clinical settings. By providing a model to study the implications of GAL3ST1 in disease, they assist in the development of targeted therapies and diagnostic markers. The potential for high-throughput screening and drug discovery is significant, as understanding the pathways influenced by GAL3ST1 can lead to novel therapeutic approaches.
When compared to alternative cell models, GAL3ST1 Gene Knockout Cell Lines offer unique advantages, such as specificity in gene disruption, reproducibility, and the availability of isogenic controls. These features ensure that experimental outcomes are attributable directly to GAL3ST1 activity rather than confounding factors.
For researchers and clinicians seeking to deepen their understanding of genetic pathways and disease processes, GAL3ST1 Gene Knockout Cell Lines present a valuable and advanced tool. They are an essential resource for pushing the boundaries of current scientific knowledge and can contribute to breakthroughs in personalized medicine and therapeutic development.
Our company has a proven track record in the production of high-quality biological products, underscored by rigorous validation processes and a commitment to supporting scientists in their quest to unlock the mysteries of biology. We strive to provide innovative solutions that enhance research and contribute to advancements in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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