Gene: Faah
Official Full Name: fatty acid amide hydrolaseprovided by MGI
Gene Summary: Enables monoacylglycerol lipase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Is active in glutamatergic synapse. Is expressed in several structures, including brain; ganglia; gut; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01082 | Faah Knockout cell line (AML12) | Mouse | Faah | 1:3~1:6 | Negative | Online Inquiry |
Faah Gene Knockout Cell Lines represent a pivotal advancement in the study of lipid signaling and metabolism, specifically focusing on the fatty acid amide hydrolase (FAAH) enzyme, which plays a crucial role in the endocannabinoid system by regulating neurotransmitter activity and various aspects of lipid metabolism. These engineered cell lines contain specific genetic modifications that result in the functional knockout of the FAAH gene, allowing for detailed investigations into the physiological and pathological roles of FAAH in various biological contexts.
The primary function of these knockout cell lines lies in their ability to facilitate the study of endocannabinoids, such as anandamide, which exert significant neuroprotective and anti-inflammatory effects. By utilizing these cell lines, researchers can investigate the nuanced pathways influenced by FAAH inhibition, leading to potential therapeutic insights in pain management, neurodegenerative disorders, and various psychiatric conditions. Furthermore, with a deeper understanding of FAAH-related mechanisms, the development of novel pharmacological agents targeting this pathway is accelerated.
What sets Faah Gene Knockout Cell Lines apart from alternative models is their precise genetic alteration, which ensures a consistent and reproducible model for studying the effects of FAAH deficiency. This specificity reduces variability and enhances the reliability of experimental outcomes. Consequently, researchers can effectively validate hypotheses regarding the role of FAH in disease models.
These knockout cell lines are invaluable tools for both academic and clinical researchers seeking to unravel the complexities of lipid mediator signaling. Their ability to mimic physiological conditions makes them particularly advantageous for drug discovery and development, yielding robust results that are directly translatable to human health.
Our company is committed to advancing biological research by offering high-quality, well-characterized gene knockout models tailored to the needs of scientists. With extensive expertise in genetic engineering and cellular biology, we provide researchers with the tools necessary to drive innovation and enhance understanding in the biomedical field.
Please note that all services are for research use only. Not intended for any clinical use.
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