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FYN Knockout Cell Lines

Gene: FYN

Official Full Name: FYN proto-oncogene, Src family tyrosine kinaseprovided by HGNC

Gene Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07745 FYN Knockout cell line (HeLa) Human FYN 1:3~1:6 Negative Online Inquiry
KO07746 FYN Knockout cell line (HCT 116) Human FYN 1:2~1:4 Negative Online Inquiry
KO07747 FYN Knockout cell line (HEK293) Human FYN 1:3~1:6 Negative Online Inquiry
KO07748 FYN Knockout cell line (A549) Human FYN 1:3~1:4 Negative Online Inquiry

Background

FYN Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the role and function of the FYN proto-oncogene. This product features a knockout of the FYN gene, providing researchers with invaluable tools to investigate the molecular pathways and cellular mechanisms influenced by FYN, which is involved in T cell activation, neuronal signaling, and several cancers. The knockout strategy effectively eliminates FYN protein expression, enabling precise evaluation of its contributions to diverse biological processes.

The critical function of FYN Gene Knockout Cell Lines lies in their ability to dissect signaling cascades and contribute to the understanding of disease mechanisms. By utilizing these cell lines, scientists can elucidate how the absence of FYN alters cellular behavior, including proliferation, apoptosis, and differentiation. This model is particularly valuable in cancer research where FYN's aberrant activation is implicated, as well as in neurobiology, where it plays a role in synaptic plasticity.

In research and clinical settings, these knockout cell lines serve as a powerful platform for drug discovery and therapeutic development, providing a robust system for screening potential inhibitors of FYN activity. Unlike conventional cell lines, which may retain variable endogenous levels of FYN, our knockout lines offer an unparalleled level of uniformity and precision, minimizing confounding variables.

The advantages of FYN Gene Knockout Cell Lines include ease of use, reproducibility, and the high level of specificity in targeting gene functions. Researchers can trust the integrity and reliability of these lines, which are rigorously validated through advanced genomic techniques.

As a leader in the field of genetic engineering and cell line development, our company is committed to providing high-quality biological tools that empower researchers and clinicians. We ensure our products meet stringent scientific standards, facilitating groundbreaking discoveries and enhancing the understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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