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FYCO1 Knockout Cell Lines

Gene: FYCO1

Official Full Name: FYVE and coiled-coil domain autophagy adaptor 1provided by HGNC

Gene Summary: The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20688 FYCO1 Knockout cell line (HeLa) Human FYCO1 1:3~1:6 Negative Online Inquiry
KO20689 FYCO1 Knockout cell line (HCT 116) Human FYCO1 1:2~1:4 Negative Online Inquiry
KO20690 FYCO1 Knockout cell line (HEK293) Human FYCO1 1:3~1:6 Negative Online Inquiry
KO20691 FYCO1 Knockout cell line (A549) Human FYCO1 1:3~1:4 Negative Online Inquiry

Background

FYCO1 Gene Knockout Cell Lines represent a pivotal advancement in molecular biology, designed specifically to facilitate the exploration of the FYCO1 gene's role within cellular processes. By utilizing CRISPR-Cas9 gene editing technology, these cell lines allow researchers to induce a complete knockout of the FYCO1 gene, thereby generating a unique model for studying the gene's functions and its implications in various physiological and pathological contexts.

The primary function of the FYCO1 Gene Knockout Cell Lines is to serve as a tool for dissecting the biological pathways influenced by FYCO1, a gene known for its involvement in autophagosome transport and cellular stress responses. By studying these knockout lines, researchers can elucidate the role of FYCO1 in cellular dynamics, including its contribution to disease mechanisms such as neurodegeneration and cancer. Mechanistically, the absence of FYCO1 alters the intracellular transport pathways, leading to an accumulation of autophagosomes and subsequent cellular stress, thus providing insights into the therapeutic targets for diseases linked to autophagy dysregulation.

The scientific significance of these cell lines extends into both research and clinical applications. They provide a robust platform for drug screening, allowing the identification of compounds that can modulate autophagy and target cancerous cells lacking functional FYCO1. Furthermore, these cell lines enhance the understanding of FYCO1's role in immune response regulation, paving the way for novel therapeutic strategies in inflammatory diseases.

One of the distinct advantages of using FYCO1 Gene Knockout Cell Lines is their unparalleled specificity and reliability, which surpasses traditional models that may produce off-target effects or variability in gene expression levels. The precise gene editing ensures that researchers are working with a definitive model that mirrors the complete absence of FYCO1, fostering reproducibility and accuracy in experimental outcomes.

For researchers and clinicians, the value of these cell lines lies in their capacity to accelerate discoveries in cell biology and disease research, thus contributing to the development of targeted therapies. Moreover, their availability makes them an essential asset for laboratories focusing on genetic and cellular studies.

Our company is dedicated to providing cutting-edge biological products that meet the rigorous standards of modern research. With expertise in gene editing technologies and a commitment to advancing scientific knowledge, we are proud to offer FYCO1 Gene Knockout Cell Lines as a valuable resource for the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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