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FSCN1 Knockout Cell Lines

Gene: FSCN1

Official Full Name: fascin actin-bundling protein 1provided by HGNC

Gene Summary: This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00107 FSCN1 Knockout cell line (HeLa) Human FSCN1 1:3~1:6 Negative Online Inquiry

Background

FSCN1 Gene Knockout Cell Lines are genetically engineered cell lines where the FSCN1 gene—responsible for the encoding of fascin, a key actin-bundling protein involved in cellular morphology and motility—has been inactivated. This powerful tool enables researchers to investigate the role of fascin in cellular processes such as migration, adhesion, and invasion, which are critical in understanding cancer metastasis and other disease mechanisms.

These cell lines are established through CRISPR-Cas9 technology, allowing for precise and efficient gene editing. By creating a complete knockout of the FSCN1 gene, researchers can analyze the phenotypic consequences of fascin loss, shedding light on its specific contributions to cytoskeletal dynamics and cell behavior under physiological and pathological conditions.

The scientific importance of FSCN1 Gene Knockout Cell Lines is particularly pronounced in oncology and developmental biology research. They provide a robust model system for studying the underlying mechanisms of tumor invasion and metastasis, as well as aiding in the characterization of cytoskeletal disorders. Furthermore, these cell lines can be used to evaluate potential therapeutic targets and drug responsiveness, proving invaluable in translational research settings.

Compared to conventional methods that may rely on knockdown approaches, which are often transient and incomplete, our FSCN1 Gene Knockout Cell Lines offer stable and heritable alterations to the genome. This stability ensures reproducible results over extended experimental periods, making it easier for researchers to draw meaningful conclusions. The specificity of gene knockout also minimizes off-target effects commonly associated with RNA interference techniques.

For researchers and clinicians focused on the cellular mechanics of disease, adopting FSCN1 Gene Knockout Cell Lines is a significant step towards elucidating complex biological processes. Our product not only enhances experimental rigor but also aligns with cutting-edge advancements in gene editing technologies. Backed by our company’s commitment to innovation and excellence in biological products, scientists can depend on our offerings to propel their research forward with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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