Gene: FN3K
Official Full Name: fructosamine 3 kinaseprovided by HGNC
Gene Summary: A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17576 | FN3K Knockout cell line (HeLa) | Human | FN3K | 1:3~1:6 | Negative | Online Inquiry |
KO17577 | FN3K Knockout cell line (HCT 116) | Human | FN3K | 1:2~1:4 | Negative | Online Inquiry |
KO17578 | FN3K Knockout cell line (HEK293) | Human | FN3K | 1:3~1:6 | Negative | Online Inquiry |
KO17579 | FN3K Knockout cell line (A549) | Human | FN3K | 1:3~1:4 | Negative | Online Inquiry |
FN3K Gene Knockout Cell Lines represent a groundbreaking approach to studying cellular metabolism and biochemical pathways by providing researchers with a powerful tool for investigating the role of the FN3K gene in cellular function. These specialized cell lines are developed through the targeted deletion of the FN3K gene, which encodes for the enzyme fructosamine 3-kinase. This enzyme plays a crucial role in the glycation/fructation process, impacting the formation of advanced glycation end-products (AGEs) and influencing cellular responses to glucose levels.
The primary function of FN3K is to regulate the metabolic processes linked to the accumulation of glycated proteins. By utilizing FN3K knockout cell lines, scientists can elucidate the pathways involved in glucose metabolism, aging, and related diseases, such as diabetes and cardiovascular disorders. The loss of FN3K expression allows for the assessment of the cellular effects of increased fructosamine levels and the subsequent influence on insulin signaling and oxidative stress, providing valuable insights into the mechanisms of metabolic dysfunction.
The scientific importance of FN3K Gene Knockout Cell Lines extends to their application in both basic and applied research, facilitating the evaluation of therapeutic interventions aimed at mitigating the impacts of glycation-related injuries. Researchers and clinicians alike can leverage these cell lines to explore novel strategies for treating metabolic diseases and enhancing our understanding of AGE-related pathologies.
What sets FN3K Gene Knockout Cell Lines apart from alternative strategies is their specificity and reliability in providing a controlled environment for studying the consequent biochemical alterations that arise from FN3K deletion. Unlike pharmacological inhibition or transient transfection methods, these stable knockout lines offer reproducible results that are essential for rigorous scientific exploration.
In summary, the FN3K Gene Knockout Cell Lines serve as a robust resource for researchers and clinicians focusing on metabolism, aging, and diabetes healthcare. By integrating this product into their research or clinical practices, users can make strides in advancing scientific knowledge and therapeutic applications. Our company is dedicated to providing high-quality biological products backed by extensive expertise and a commitment to supporting cutting-edge research.
Please note that all services are for research use only. Not intended for any clinical use.
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