Home / FIG4 Knockout Cell Lines

FIG4 Knockout Cell Lines

Gene: FIG4

Official Full Name: FIG4 phosphoinositide 5-phosphataseprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01522 FIG4 Knockout cell line (HeLa) Human FIG4 1:3~1:6 Negative Online Inquiry
KO01523 FIG4 Knockout cell line (HCT 116) Human FIG4 1:2~1:4 Negative Online Inquiry
KO01524 FIG4 Knockout cell line (HEK293) Human FIG4 1:3~1:6 Negative Online Inquiry
KO01525 FIG4 Knockout cell line (A549) Human FIG4 1:3~1:4 Negative Online Inquiry

Background

FIG4 Gene Knockout Cell Lines are specialized cellular models engineered to have the FIG4 gene inactivated, providing valuable tools for the interrogation of gene function and associated biological pathways. Specifically, FIG4 is a vital gene implicated in phosphoinositide metabolism and lysosomal function; the loss of its function is associated with neurodegenerative conditions such as Charcot-Marie-Tooth disease and other neuropathies. By utilizing these knockout cell lines, researchers can elucidate the physiological role of FIG4 and investigate the downstream effects of its loss, thereby advancing our understanding of disease mechanisms.

The key functionality of FIG4 Gene Knockout Cell Lines lies in their ability to mimic human disease states. Researchers can analyze cellular behavior, including morphology, signaling pathways, and molecular interactions, which are crucial for drug screening and therapeutic development. The complete ablation of the FIG4 gene allows investigators to monitor compensatory mechanisms and assess the impact on cellular homeostasis, making it a powerful model for targeted experimental studies.

Scientifically, these cell lines serve diverse applications within both basic and translational research contexts. They are pivotal for studying lysosomal trafficking, testing potential pharmaceuticals, and exploring genetic contributions to neurological disorders. Moreover, they offer a platform for high-throughput screening assays, enabling rapid identification of compounds that could restore FIG4 function or mitigate its consequences in disease.

What sets our FIG4 Gene Knockout Cell Lines apart from alternatives is their superior reliability and the comprehensive validation of gene knockout efficiency, confirming complete FIG4 inactivation. Our cell lines are derived from well-characterized backgrounds, ensuring consistency across experimental replicates and enhanced reproducibility of results.

For researchers and clinicians, the value of utilizing FIG4 Gene Knockout Cell Lines cannot be overstated. They provide a foundation for cutting-edge research that may lead to breakthroughs, targeted gene therapies, and insights into the pathogenesis of neurodegenerative diseases. By choosing our product, users tap into years of expertise and commitment to quality that our company brings to the development of advanced biological products, ultimately enhancing their research outcomes and clinical innovations.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.