Gene: FGFRL1
Official Full Name: fibroblast growth factor receptor like 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21916 | FGFRL1 Knockout cell line (HeLa) | Human | FGFRL1 | 1:3~1:6 | Negative | Online Inquiry |
KO21917 | FGFRL1 Knockout cell line (HCT 116) | Human | FGFRL1 | 1:2~1:4 | Negative | Online Inquiry |
KO21918 | FGFRL1 Knockout cell line (HEK293) | Human | FGFRL1 | 1:3~1:6 | Negative | Online Inquiry |
KO21919 | FGFRL1 Knockout cell line (A549) | Human | FGFRL1 | 1:3~1:4 | Negative | Online Inquiry |
FGFRL1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to lack the FGFRL1 gene, a member of the fibroblast growth factor receptor (FGFR) family. The FGFRL1 gene encodes a receptor that plays a critical role in various cellular processes, including cell growth, survival, and differentiation. By knocking out this gene, researchers can investigate the downstream effects of its absence, thereby illuminating the gene's involvement in physiological and pathological processes, such as cancer progression and developmental disorders.
The primary function of FGFRL1 Gene Knockout Cell Lines is to serve as a tool for biologists to manipulate and observe the biological consequences of FGFRL1 depletion. This specific cellular model allows for the study of altered signaling pathways, providing insights into how FGFRL1 contributes to cellular behavior. Such models are invaluable for researchers aiming to uncover the mechanistic aspects of diseases related to aberrant FGFR signaling and to identify potential therapeutic targets for intervention.
In scientific and clinical research settings, these cell lines hold substantial importance. They can be employed in high-throughput screening of compounds that could modulate the signaling pathways influenced by FGFRL1, paving the way for novel drug development. These cell lines are particularly advantageous in cancer research, where understanding tumor microenvironments and cell signaling is paramount in developing effective therapies.
What distinguishes FGFRL1 Gene Knockout Cell Lines from other genetic models is their specificity and the established, reliable methodology used for their creation. Many alternative models may not fully replicate the complex interactions that FGFRL1 mediates, which can lead to inaccuracies in research outcomes. Additionally, these knockout lines streamline experimental protocols, saving time and resources while enhancing reproducibility in findings.
For researchers and clinicians alike, the FGFRL1 Gene Knockout Cell Lines represent an invaluable asset that enhances their capacity to explore and advance therapeutic strategies against diseases related to FGFR dysfunction. By leveraging years of expertise in genetic engineering and cell line development, our company is committed to providing high-quality biological products that support groundbreaking research and drive clinical innovation.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.