Gene: FGFR2
Official Full Name: fibroblast growth factor receptor 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10788 | FGFR2 Knockout cell line (HCT 116) | Human | FGFR2 | 1:2~1:4 | Negative | Online Inquiry |
KO10789 | FGFR2 Knockout cell line (HEK293) | Human | FGFR2 | 1:3~1:6 | Negative | Online Inquiry |
FGFR2 Gene Knockout Cell Lines are genetically engineered cell lines produced to have targeted deletions in the Fibroblast Growth Factor Receptor 2 (FGFR2) gene. The FGFR2 protein plays a critical role in cell migration, proliferation, and differentiation, particularly during embryonic development and in various physiological processes. By employing CRISPR-Cas9 technology or other gene editing techniques, these cell lines facilitate the investigation of FGFR2's biological functions and its implications in diseases such as cancer, developmental disorders, and fibrosis.
The primary function of FGFR2 Gene Knockout Cell Lines lies in their utility as a model for understanding the pathogenic mechanisms associated with aberrant FGFR2 signaling. The knockout of this gene enables researchers to elucidate downstream signaling pathways, study cellular responses to growth factors, and assess changes in cellular behavior affecting tumor progression and metastasis. Additionally, these models can aid in the screening and development of therapeutic strategies targeting FGFR2-driven malignancies.
In scientific research and clinical applications, FGFR2 Gene Knockout Cell Lines are invaluable for translational studies. They provide a platform for drug discovery and testing in a controlled environment that mimics the relevant biological context. The targeted manipulation of FGFR2 allows for refined assessments of ligand-receptor interactions and the development of potential treatments that could inhibit or modulate these pathways.
What sets our FGFR2 Gene Knockout Cell Lines apart from alternative products is the precision of our gene editing process, ensuring that unintentional off-target effects are minimized. Furthermore, our extensive validation across various assays provides confidence in their reliability and reproducibility. Researchers can thus gain robust data that can lead to significant advancements in their work.
In summary, FGFR2 Gene Knockout Cell Lines represent a critical tool for exploring fundamental biological questions and developing novel therapeutic approaches. Our company brings years of expertise in genetic engineering and cell line development, ensuring that we offer high-quality, reliable products that empower researchers and clinicians to achieve groundbreaking discoveries in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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