Gene: FGF14
Official Full Name: fibroblast growth factor 14provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00064 | FGF14 Knockout cell line (H9) | Human | FGF14 | 1:6-1:8 | Negative | Online Inquiry |
FGF14 Gene Knockout Cell Lines represent a cutting-edge tool for the investigation of fibroblast growth factor 14 (FGF14) and its intricate roles in cellular function and disease pathways. These genetically engineered cell lines have been specifically designed to lack the FGF14 gene, allowing researchers to study the absence of this protein's signaling pathways and its impacts on cell differentiation, proliferation, and response to physiological stimuli.
The key mechanism behind these knockout cell lines involves homologous recombination technology, which replaces the native FGF14 gene with a selectable marker. This precise editing ensures the complete disruption of FGF14 expression, providing researchers with a reliable model to investigate the biological consequences of FGF14 knockouts. Understanding the nuances of FGF14's signaling pathways is crucial, as this protein has been implicated in a variety of neurological conditions and cardiac dysfunction.
The scientific importance of FGF14 Gene Knockout Cell Lines is underscored by their diverse applications in both basic research and clinical settings. They enable exploration into neurological diseases, such as epilepsy and schizophrenia, as well as cardiac disorders associated with altered FGF signaling. This can lead to novel therapeutic strategies and provide valuable insights into disease mechanisms.
One of the standout advantages of utilizing FGF14 Gene Knockout Cell Lines is their high specificity and reproducibility, which is critical for generating robust data. Unlike less targeted approaches, these dedicated cell lines can yield clearer experimental outcomes, thus enhancing the reliability of your research findings. Furthermore, they eliminate the complications associated with off-target effects, which can confound results with other models.
Researchers and clinicians stand to benefit immensely from integrating FGF14 Gene Knockout Cell Lines into their studies, as they present unparalleled opportunities to unravel the biological underpinnings of disorders linked to FGF signaling. By selecting this tool, scientists can push the boundaries of understanding in a rapidly evolving field, ultimately driving innovative treatment options for patients.
As a leader in the development of advanced biological products, our company leverages extensive expertise and state-of-the-art technologies to provide high-quality tools like the FGF14 Gene Knockout Cell Lines. We are committed to empowering researchers and clinicians with the resources they need to make groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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