Gene: FGB
Official Full Name: fibrinogen beta chainprovided by HGNC
Gene Summary: The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04383 | FGB Knockout cell line (A549) | Human | FGB | 1:3~1:4 | Negative | Online Inquiry |
FGB Gene Knockout Cell Lines are strategically developed biological tools designed for researchers studying the functional roles of the fibrinogen gene (FGB) within varying biological contexts. These cell lines have been engineered through advanced CRISPR/Cas9 gene-editing techniques to lack the expression of FGB, allowing for comprehensive investigations into its contributions to physiological and pathological processes, particularly in hemostasis and inflammation.
The primary function of the FGB Gene Knockout Cell Lines is to provide an experimental platform for elucidating the genetic and molecular underpinnings of diseases linked to aberrant fibrinogen activity. Through the precise deletion of the FGB gene, researchers can observe the resultant phenotypic changes, cellular signaling pathways, and gene interaction networks. This knockout approach offers insights that are crucial for deciphering the complex roles fibrinogen plays in thrombogenesis, immune responses, and tissue repair mechanisms.
Scientifically, these cell lines are invaluable in both research and clinical settings, facilitating the development of targeted therapies for conditions such as cardiovascular diseases, where fibrinogen is a key player. Their application extends to drug discovery and testing, as understanding FGB’s role could lead to more effective treatments and interventions.
One of the standout advantages of FGB Gene Knockout Cell Lines compared to alternative models is their specificity; the complete deletion of the target gene minimizes off-target effects, enhancing the reliability of experimental results. Furthermore, their ease of use and compatibility with high-throughput screening assays position them as an optimal choice for modern laboratories aiming for efficiency and efficacy.
For researchers and clinicians focused on advancing therapeutic modalities or unraveling genetic mechanisms, FGB Gene Knockout Cell Lines represent an essential asset. Their introduction into experimental frameworks can significantly enhance the resolution of research insights and therapeutic strategies.
Our company prides itself on its commitment to cutting-edge research and quality production of biological models. We leverage extensive expertise in gene editing to offer researchers robust tools that drive scientific innovation and discovery within their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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