Gene: FBXW5
Official Full Name: F-box and WD repeat domain containing 5provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21753 | FBXW5 Knockout cell line (HeLa) | Human | FBXW5 | 1:3~1:6 | Negative | Online Inquiry |
KO21754 | FBXW5 Knockout cell line (HCT 116) | Human | FBXW5 | 1:2~1:4 | Negative | Online Inquiry |
KO21755 | FBXW5 Knockout cell line (HEK293) | Human | FBXW5 | 1:3~1:6 | Negative | Online Inquiry |
KO21756 | FBXW5 Knockout cell line (A549) | Human | FBXW5 | 1:3~1:4 | Negative | Online Inquiry |
FBXW5 Gene Knockout Cell Lines are advanced genetic models generated to facilitate the study of the FBXW5 gene, which encodes a member of the F-box protein family involved in the ubiquitin-proteasome pathway. These cell lines provide researchers with a powerful tool to investigate the roles of FBXW5 in cellular processes such as protein degradation, cell cycle regulation, and signaling pathways that are crucial for maintaining cellular homeostasis.
The key function of FBXW5 Gene Knockout Cell Lines lies in their ability to eliminate the expression of the FBXW5 gene, allowing for the direct observation of the phenotypic and molecular changes resulting from this targeted knockout. By utilizing CRISPR-Cas9 gene editing technology, the cell lines maintain a robust genetic background, ensuring that observed effects are specifically attributable to the loss of FBXW5 function. Consequently, they are invaluable for elucidating the gene's contributions to various pathophysiological conditions, including cancer, where dysregulation of the ubiquitin-proteasome system frequently occurs.
From a scientific standpoint, these knockout cell lines are essential in research settings aimed at understanding the mechanistic pathways underlying diseases and developing potential therapeutic interventions. They can be employed in drug screening assays, gene function studies, and cellular response evaluations, thus broadening the scope of research applications.
Compared to alternative models, FBXW5 Gene Knockout Cell Lines provide heightened specificity and control, enabling researchers to directly manipulate and observe the consequences of gene deletion with minimal confounding factors. The established genetic stability of these cell lines further enhances reproducibility and reliability, making them a preferred choice for both academic and industrial research environments.
With a commitment to advancing biological research, our company offers extensive expertise in the development of high-quality genetic models. Our FBXW5 Gene Knockout Cell Lines exemplify this dedication, providing researchers and clinicians with the innovative tools necessary to push the boundaries of genetic research and therapeutic discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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