Gene: FBXO9
Official Full Name: F-box protein 9provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28142 | FBXO9 Knockout cell line (HeLa) | Human | FBXO9 | 1:3~1:6 | Negative | Online Inquiry |
KO28143 | FBXO9 Knockout cell line (HCT 116) | Human | FBXO9 | 1:2~1:4 | Negative | Online Inquiry |
KO28144 | FBXO9 Knockout cell line (HEK293) | Human | FBXO9 | 1:3~1:6 | Negative | Online Inquiry |
KO28145 | FBXO9 Knockout cell line (A549) | Human | FBXO9 | 1:3~1:4 | Negative | Online Inquiry |
FBXO9 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the functional expression of the FBXO9 gene, a member of the F-box protein family that plays a crucial role in the ubiquitin-proteasome system, emphasizing its importance in cellular processes such as protein degradation and cell cycle regulation. By utilizing CRISPR-Cas9 technology, these cell lines offer researchers a reliable model to study the physiological implications of FBXO9 loss, enabling a deeper understanding of its role in various biological contexts.
The key function of the FBXO9 knockout lies in its ability to disrupt normal cellular signaling pathways. FBXO9 is involved in the ubiquitination of target proteins, leading to their degradation or modification, which is essential for maintaining cellular homeostasis. By using these knockout cell lines, researchers can investigate the consequences of FBXO9 deficiency, including alterations in cell growth, differentiation, and apoptosis, offering insights into the gene’s potential involvement in cancer, immune responses, and metabolic disorders.
Scientifically, FBXO9 Gene Knockout Cell Lines are invaluable for both academic and clinical research. They provide a powerful tool for investigating the molecular pathways that underlie diseases and for validating therapeutic targets. Additionally, these models facilitate the study of drug responses and resistance mechanisms, enhancing their potential for translational research.
Compared to traditional cell lines that express the FBXO9 gene, these knockout models offer a more precise approach to studying gene function, eliminating variability in results and allowing for clearer interpretations. They represent a breakthrough in gene editing technology that is not only effective but also user-friendly for researchers with various levels of expertise in molecular biology.
For researchers and clinicians alike, the value of FBXO9 Gene Knockout Cell Lines is underscored by their ability to expedite the discovery of novel therapeutic strategies and improve our understanding of cellular mechanisms. Our company prides itself on providing high-quality, state-of-the-art biological products, and we are committed to advancing the field of research through innovative solutions such as our FBXO9 knockout models.
Please note that all services are for research use only. Not intended for any clinical use.
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