Gene: FBXO33
Official Full Name: F-box protein 33provided by HGNC
Gene Summary: This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21174 | FBXO33 Knockout cell line (HeLa) | Human | FBXO33 | 1:3~1:6 | Negative | Online Inquiry |
KO21175 | FBXO33 Knockout cell line (HCT 116) | Human | FBXO33 | 1:2~1:4 | Negative | Online Inquiry |
KO21176 | FBXO33 Knockout cell line (HEK293) | Human | FBXO33 | 1:3~1:6 | Negative | Online Inquiry |
KO21177 | FBXO33 Knockout cell line (A549) | Human | FBXO33 | 1:3~1:4 | Negative | Online Inquiry |
FBXO33 Gene Knockout Cell Lines are specialized cell lines engineered to have a targeted knockout of the FBXO33 gene, which encodes for a member of the F-box protein family. This family is integral to the ubiquitin-proteasome system, facilitating the ubiquitination and subsequent degradation of specific substrates. The loss of FBXO33 function allows researchers to dissect its role in cellular processes such as apoptosis, differentiation, and signal transduction pathways. By studying these knockout cell lines, scientists can gain insights into the molecular mechanisms influenced by FBXO33 and its involvement in various diseases, including cancer.
One of the key functions of FBXO33 is its ability to regulate protein turnover, influencing cellular homeostasis and stress responses. The knockout of this gene may result in altered cellular phenotypes and expression profiles, offering a valuable tool for understanding gene function in a controlled environment. The applications of FBXO33 knockout cell lines extend from foundational research in cellular biology to translational studies in drug development and therapeutic interventions, highlighting their significance in both basic and applied science.
Notably, the specific advantage of using FBXO33 Gene Knockout Cell Lines lies in their precise gene modification and reproducibility in experimental setups. Unlike traditional methods of gene silencing, such as siRNA or antisense oligonucleotides, knockout cell lines provide a stable model for long-term studies, enabling more rigorous assessments of phenotypic outcomes and mechanistic insights. Furthermore, the ability to compare knockout lines against wild-type controls enhances the depth of research findings.
For researchers and clinicians eager to unravel the complexities of gene function and disease pathways, FBXO33 Gene Knockout Cell Lines represent an invaluable asset. They provide a unique platform for the exploration of the ubiquitin-proteasome system and its implications in cellular regulation and pathology.
At our company, we pride ourselves on our expertise in producing high-quality genetically modified cell lines that support innovative research across a range of biological disciplines. Our commitment to scientific excellence ensures that our products empower the research community to explore and discover with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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