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FBXL8 Knockout Cell Lines

Gene: FBXL8

Official Full Name: F-box and leucine rich repeat protein 8provided by HGNC

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17676 FBXL8 Knockout cell line (HeLa) Human FBXL8 1:3~1:6 Negative Online Inquiry
KO17677 FBXL8 Knockout cell line (HCT 116) Human FBXL8 1:2~1:4 Negative Online Inquiry
KO17678 FBXL8 Knockout cell line (HEK293) Human FBXL8 1:3~1:6 Negative Online Inquiry
KO17679 FBXL8 Knockout cell line (A549) Human FBXL8 1:3~1:4 Negative Online Inquiry

Background

FBXL8 Gene Knockout Cell Lines are specially engineered cellular models that facilitate the study of the FBXL8 gene's role in various biological processes. Through the targeted deletion of the FBXL8 gene using advanced CRISPR/Cas9 gene-editing technology, these cell lines provide researchers with invaluable tools to investigate the functional consequences of gene loss and its implications in cellular signaling, proliferation, and differentiation.

The primary mechanism by which FBXL8 Gene Knockout Cell Lines operate is through the silencing of the FBXL8 gene, which encodes for a member of the F-box protein family involved in the ubiquitin-proteasome system. This disruption allows scientists to observe the phenotypic changes that result from altered signaling pathways and protein turnover. By assessing cellular responses to environmental stimuli or pharmacological treatments, researchers can gain insights into the gene's physiological and pathological roles.

Scientifically, FBXL8 Gene Knockout Cell Lines hold tremendous importance for both fundamental and applied research. They serve as key models to elucidate the cellular basis of disorders where FBXL8 is implicated, such as certain cancers and metabolic diseases. In clinical settings, these cell lines are instrumental in drug discovery, where they can be utilized to test the efficacy of novel therapeutics aimed at modulating the functions associated with the FBXL8 pathway.

Compared to traditional cell lines that express the FBXL8 gene, our knockout models deliver unambiguous results, minimizing variability and enhancing reproducibility, which is crucial for obtaining reliable data. The precise knockout ensures a more straightforward interpretation of experimental outcomes, enabling researchers to design more effective studies.

For researchers and clinicians looking to deepen their understanding of gene functions and test therapeutic strategies, FBXL8 Gene Knockout Cell Lines are exceptional assets. With our commitment to high-quality products, we leverage our extensive expertise in genetic engineering and cell line development to provide state-of-the-art tools that empower scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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