Gene: FBXL7
Official Full Name: F-box and leucine rich repeat protein 7provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29720 | FBXL7 Knockout cell line (HEK293) | Human | FBXL7 | 1:3~1:6 | Negative | Online Inquiry |
KO29721 | FBXL7 Knockout cell line (A549) | Human | FBXL7 | 1:3~1:4 | Negative | Online Inquiry |
FBXL7 Gene Knockout Cell Lines represent a specialized biological tool designed for researchers investigating the functional role of the FBXL7 gene in various cellular processes. These cell lines have been meticulously engineered to exhibit a targeted deletion of the FBXL7 gene, allowing for the exploration of its contributions to cellular pathways, including cell cycle regulation, protein degradation, and oncogenesis.
The primary function of these knockout cell lines lies in their ability to facilitate in-depth studies of gene function and the phenotypic consequences of gene loss. By systematically removing FBXL7, researchers can observe changes in cellular behavior, protein interactions, and signaling pathways, providing crucial insights into the gene's involvement in disease states such as cancer. The mechanism of action enables the isolation of specific biological effects attributable to the absence of FBXL7, paving the way for the identification of potential therapeutic targets.
The scientific importance of FBXL7 Gene Knockout Cell Lines is underscored by their versatility in both basic and applied research settings. They serve as powerful models for studying cell biology, drug response, and genetic interactions, making them valuable assets in the development of novel therapeutics. Their applications in preclinical studies could lead to breakthroughs in understanding tumor biology and the mechanistic roles of FBXL7 in health and disease.
What distinguishes FBXL7 Gene Knockout Cell Lines from alternative models is their precise genetic modification and the high reproducibility of experimental results. This level of specificity ensures that researchers can attribute observed effects directly to the knockout of FBXL7, reducing variables that could confound results in more heterogeneous systems. Moreover, the availability of these cell lines through reliable sources guarantees access to well-characterized and quality-assured models.
In conclusion, the FBXL7 Gene Knockout Cell Lines offer immense value to researchers and clinicians by enabling a clearer understanding of the gene's role in important biological processes and diseases. With our company’s commitment to providing high-quality research tools, backed by extensive expertise in genetic engineering, researchers can rely on our products to drive their scientific inquiries forward, ensuring they are equipped to make impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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