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FBXL3 Knockout Cell Lines

Gene: FBXL3

Official Full Name: F-box and leucine rich repeat protein 3provided by HGNC

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28217 FBXL3 Knockout cell line (HeLa) Human FBXL3 1:3~1:6 Negative Online Inquiry
KO28218 FBXL3 Knockout cell line (HCT 116) Human FBXL3 1:2~1:4 Negative Online Inquiry
KO28219 FBXL3 Knockout cell line (HEK293) Human FBXL3 1:3~1:6 Negative Online Inquiry
KO28220 FBXL3 Knockout cell line (A549) Human FBXL3 1:3~1:4 Negative Online Inquiry

Background

FBXL3 Gene Knockout Cell Lines are genetically engineered cellular models that have had the FBXL3 gene selectively inactivated, allowing researchers to study the biological role of this gene in various pathways. The FBXL3 gene encodes a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system, fundamental for protein degradation and regulation of cellular processes. By knocking out FBXL3, users can elucidate its impact on circadian rhythms, cell proliferation, and apoptosis, providing insights into its involvement in diseases such as cancer and metabolic disorders.

The key functionality of these cell lines lies in their ability to mimic the physiological consequences of FBXL3 loss. Researchers can utilize these models to assess alterations in gene expression, protein stability, and pathway activity, thereby understanding the downstream effects of FBXL3 knockout. This system is particularly beneficial for investigating the mechanistic role of FBXL3 in specific biological contexts, such as the regulation of circadian clocks or responses to cellular stressors.

The scientific importance of FBXL3 Gene Knockout Cell Lines extends to their applications in both fundamental research and clinical settings. They provide a valuable tool for drug discovery efforts targeting circadian-related disorders and for examining the effects of novel therapeutics that may modulate the ubiquitin-proteasome pathway. Additionally, these cell lines contribute to the understanding of molecular mechanisms underlying various human diseases, offering potential for the development of targeted therapies.

Compared to alternatives, such as transient expression systems or non-targeted knockout models, FBXL3 Gene Knockout Cell Lines offer a more stable and reproducible platform for investigating gene function. Their well-characterized genetic background provides a reliable reference point for comparative studies, ultimately facilitating faster and more accurate experimental outcomes.

For researchers and clinicians, the availability of FBXL3 Gene Knockout Cell Lines represents a significant resource that enhances the ability to conduct rigorous, high-throughput studies at the molecular level. They empower scientists to unlock the complexities of FBXL3 and its role in health and disease, accelerating the translation of findings into therapeutic applications.

At our company, we are dedicated to providing high-quality biological products backed by our commitment to innovation and scientific excellence. Our expertise in genetic engineering ensures that we offer reliable and effective tools for addressing the challenges faced by researchers today.

Please note that all services are for research use only. Not intended for any clinical use.

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