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FBRS Knockout Cell Lines

Gene: FBRS

Official Full Name: fibrosinprovided by HGNC

Gene Summary: Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17684 FBRS Knockout cell line (HeLa) Human FBRS 1:3~1:6 Negative Online Inquiry
KO17685 FBRS Knockout cell line (HCT 116) Human FBRS 1:2~1:4 Negative Online Inquiry
KO17686 FBRS Knockout cell line (HEK293) Human FBRS 1:3~1:6 Negative Online Inquiry
KO17687 FBRS Knockout cell line (A549) Human FBRS 1:3~1:4 Negative Online Inquiry

Background

FBRS Gene Knockout Cell Lines are specifically engineered cellular models designed to eliminate the expression of the fibroblast growth factor receptor substrate (FBRS) gene. These cell lines utilize CRISPR-Cas9 technology, a revolutionary genome editing tool that enables precise modifications in mammalian genomes, ensuring the complete knockout of the FBRS gene. This genetic alteration facilitates the investigation of FBRS functions in various biological pathways related to cellular proliferation, differentiation, and response to extracellular signals.

The primary mechanism by which FBRS gene knockout cell lines function involves disrupting the signaling pathways associated with fibroblast growth factor (FGF) signaling. By eliminating FBRS, researchers can elucidate the downstream effects on cell behavior, particularly in contexts such as cancer research, developmental biology, and regenerative medicine. Previous studies have suggested that FBRS plays a significant role in mediating the effects of FGF signaling, making these knockout models essential for understanding its contributions to disease processes and therapeutic responses.

From a scientific perspective, the utility of these cell lines extends beyond basic research; they hold promise for clinical applications, particularly in developing targeted therapies and personalized medicine strategies. By providing insights into how FBRS influences tumorigenesis and tissue regeneration, researchers can identify novel therapeutic targets or biomarkers for patient stratification.

What sets FBRS Gene Knockout Cell Lines apart from alternative models is their high specificity, efficiency, and the thorough validation process they undergo to confirm the successful gene knockout and functional characterization. Unlike traditional knockdown approaches, which may yield incomplete or transient silencing effects, our knockout solutions provide a stable and long-term means to study the gene of interest.

For researchers and clinicians, these cell lines represent a valuable tool that can accelerate the discovery of new therapeutic strategies and enhance the reproducibility of experimental results. The biological relevancy of FBRS in various disease processes further amplifies their importance for translational research.

Our company prides itself on its expertise in developing innovative biological tools that empower the scientific community. With a strong commitment to quality and customer support, we ensure that our products meet the rigorous standards required for cutting-edge research. With FBRS Gene Knockout Cell Lines, we aim to provide researchers with a reliable resource that contributes to the advancement of science and health.

Please note that all services are for research use only. Not intended for any clinical use.

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