Gene: FARP1
Official Full Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1provided by HGNC
Gene Summary: This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32217 | FARP1 Knockout cell line (HeLa) | Human | FARP1 | 1:3~1:6 | Negative | Online Inquiry |
KO32218 | FARP1 Knockout cell line (HCT 116) | Human | FARP1 | 1:2~1:4 | Negative | Online Inquiry |
KO32219 | FARP1 Knockout cell line (HEK293) | Human | FARP1 | 1:3~1:6 | Negative | Online Inquiry |
KO32220 | FARP1 Knockout cell line (A549) | Human | FARP1 | 1:3~1:4 | Negative | Online Inquiry |
FARP1 Gene Knockout Cell Lines are genetically engineered cellular models that specifically lack the FARP1 (FERM and PDZ domain containing 1) gene, which plays a critical role in various signaling pathways, particularly in cellular differentiation and cytoskeletal dynamics. By providing researchers access to these cell lines, they can investigate the functional implications of FARP1 ablation and its effects on cellular behavior, including motility, proliferation, and apoptosis.
The key mechanism by which FARP1 functions is through its modulation of actin dynamics and interactions with growth factor receptors, impacting downstream signaling pathways such as those governing cell migration and adhesion. The absence of the FARP1 gene can lead to observable changes in cellular morphology and behavior, making these knockout lines invaluable for understanding the gene’s network of interactions and contributions to key physiological processes.
The scientific importance of FARP1 Gene Knockout Cell Lines lies in their widespread applicability in molecular and cell biology research. They are instrumental in elucidating the role of FARP1 in diseases such as cancer and neurodegenerative disorders, thereby aiding in the discovery of potential therapeutic targets. Additionally, these cell lines are beneficial for drug screening and toxicology studies, providing insights into how targeting FARP1 might alter cellular responses.
Compared to alternative models, FARP1 Gene Knockout Cell Lines offer a specific and targeted approach, eliminating the confounding effects that could arise from using wild-type cells. Their ease of use in high-throughput screening formats and consistent performance in various assays position them as a superior choice for researchers.
Researchers, clinicians, and biotechnology companies will find these cell lines invaluable resources, driving forward innovative research and potential therapeutic advancements. Our commitment to delivering high-quality biological products, backed by extensive expertise in genetic engineering and cell line development, ensures that our FARP1 Gene Knockout Cell Lines meet the rigorous demands of modern research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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