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FAR2 Knockout Cell Lines

Gene: FAR2

Official Full Name: fatty acyl-CoA reductase 2provided by HGNC

Gene Summary: This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17701 FAR2 Knockout cell line (HeLa) Human FAR2 1:3~1:6 Negative Online Inquiry
KO17702 FAR2 Knockout cell line (HCT 116) Human FAR2 1:2~1:4 Negative Online Inquiry
KO17703 FAR2 Knockout cell line (HEK293) Human FAR2 1:3~1:6 Negative Online Inquiry

Background

FAR2 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to eliminate the expression of the FAR2 gene, which encodes a fatty acid reductase involved in lipid metabolism. These knockout models offer researchers a powerful tool for investigating the role of FAR2 in various biological processes and diseases, particularly those related to metabolic disorders, cancer, and inflammation.

The key function of FAR2 Gene Knockout Cell Lines lies in their ability to mimic the absence of FAR2 activity, allowing scientists to delve into the biological consequences of its loss. This is achieved through CRISPR-Cas9 technology, a precise genome-editing technique that creates double-strand breaks at the target gene, leading to its deletion and subsequent functional analysis. By studying these knockout lines, researchers can elucidate the pathways affected by FAR2, revealing its contribution to fatty acid metabolism and potential interactions with other metabolic networks.

From a scientific perspective, these cell lines are invaluable in both research and clinical settings. They serve as critical models for understanding the mechanistic underpinnings of metabolic diseases and can facilitate the development of targeted therapies. Additionally, FAR2 knockout lines have implications in cancer research, providing insights into how alterations in lipid metabolism can influence tumorigenesis and metastasis.

What sets FAR2 Gene Knockout Cell Lines apart from alternatives is their specificity and reliability. Unlike traditional methods of gene manipulation, such as RNA interference, these knockout lines provide a complete and stable loss of gene function, enabling clearer interpretations of experimental outcomes. This specificity reduces off-target effects and enhances the reproducibility of results, making them an optimal choice for discerning the functional role of the FAR2 gene.

For researchers and clinicians seeking to advance their studies in lipid biology and its disorders, incorporating FAR2 Gene Knockout Cell Lines presents a unique opportunity to push the boundaries of knowledge in this critical area. Our company is dedicated to providing high-quality biological tools and expertise, reinforcing our commitment to supporting groundbreaking research with innovative products tailored to meet the needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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