Gene: FANCL
Official Full Name: FA complementation group Lprovided by HGNC
Gene Summary: This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17704 | FANCL Knockout cell line (HeLa) | Human | FANCL | 1:3~1:6 | Negative | Online Inquiry |
KO17705 | FANCL Knockout cell line (HCT 116) | Human | FANCL | 1:2~1:4 | Negative | Online Inquiry |
KO17706 | FANCL Knockout cell line (HEK293) | Human | FANCL | 1:3~1:6 | Negative | Online Inquiry |
KO17707 | FANCL Knockout cell line (A549) | Human | FANCL | 1:3~1:4 | Negative | Online Inquiry |
FANCL Gene Knockout Cell Lines are specially engineered cellular systems designed to facilitate the study of gene function by providing loss-of-function models. These cell lines are generated through precise gene-editing techniques, predominantly utilizing CRISPR-Cas9, to completely disrupt the target gene, allowing researchers to investigate its biological role and contribution to various cellular processes.
The core function of FANCL Gene Knockout Cell Lines lies in their ability to provide insights into gene regulation, signaling pathways, and cellular responses by observing the phenotypic outcomes resulting from gene inactivation. By studying these knockout cell lines, researchers can elucidate the mechanistic pathways involved in disease states, gene interactions, and functional compensation between genes. Such capabilities are invaluable in both foundational research and translational studies, as they enable a deeper understanding of the genetic architecture underlying health and disease.
The scientific importance of FANCL Gene Knockout Cell Lines resonates throughout various research disciplines, including molecular biology, pharmacology, and cancer research. They serve as crucial tools for drug discovery and the development of targeted therapies, offering robust models for screening potential therapeutic compounds and evaluating their efficacy in a controlled environment.
One of the standout advantages of FANCL Gene Knockout Cell Lines is their reproducibility and reliability, which surpass many traditional methods of gene silencing such as RNA interference. The permanent gene knockout enables consistent and long-term studies, crucial for experiments focused on chronic conditions or prolonged exposure to therapeutic agents. Additionally, these cell lines come with a comprehensive support system from our expert team, ensuring users have access to guidance and troubleshooting advice when required.
For researchers and clinicians dedicated to unraveling the complexities of gene functions and investigating innovative therapeutic approaches, FANCL Gene Knockout Cell Lines prove to be an essential addition to their toolkit. With our extensive experience in gene editing technologies and commitment to high-quality biological products, we stand ready to support your scientific endeavors through this advanced product offering.
Please note that all services are for research use only. Not intended for any clinical use.
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