Gene: FAM136A
Official Full Name: family with sequence similarity 136 member Aprovided by HGNC
Gene Summary: This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24484 | FAM136A Knockout cell line (HeLa) | Human | FAM136A | 1:3~1:6 | Negative | Online Inquiry |
KO24485 | FAM136A Knockout cell line (HCT 116) | Human | FAM136A | 1:2~1:4 | Negative | Online Inquiry |
KO24486 | FAM136A Knockout cell line (HEK293) | Human | FAM136A | 1:3~1:6 | Negative | Online Inquiry |
FAM136A Gene Knockout Cell Lines represent a groundbreaking advancement in the field of genetic research, specifically designed to facilitate the exploration of the FAM136A gene's functions and its implications in various biological processes. These engineered cell lines feature a precise knockout of the FAM136A gene, allowing researchers to study the gene's role in cellular functions such as proliferation, differentiation, and stress responses without the confounding effects of normal gene expression.
The primary mechanism underlying these knockout cell lines involves CRISPR/Cas9 technology, which enables targeted editing of the genomic DNA. By inducing double-strand breaks at specific locations within the FAM136A gene and subsequently guiding the cellular repair mechanisms to produce a non-functional allele, the resulting cell lines provide a clean genetic model for evaluating the consequences of FAM136A absence. Researchers can employ these lines in functional assays, gene expression analyses, and drug response studies, elucidating the gene's involvement in various diseases, including cancer and neurodegenerative disorders.
The scientific importance of FAM136A Gene Knockout Cell Lines is immense, as they open avenues for both fundamental research and therapeutic explorations. The ability to directly observe the phenotypic consequences of gene knockout fosters a deeper understanding of gene function, which can lead to potential indications for gene therapy or other treatment modalities. Compared to other gene-editing methods, such as RNA interference, CRISPR/Cas9 provides a more permanent and specific alteration of the genome, allowing for long-term studies of gene function in cell lines.
This product is invaluable to researchers and clinicians who require dependable models devoid of biological variability inherent to wild-type cells. Additionally, the functional insights derived from using these knockout cell lines can significantly expedite drug discovery processes, improving the efficiency of preclinical testing and enhancing the translational potential of research findings.
Our company prides itself on its expertise in providing high-quality biological products tailored to meet the dynamic needs of the scientific community. With an unwavering commitment to innovation and customer support, we aim to empower researchers with tools that advance biological discovery and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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